16897-97-5

Basic information

• Product Name: 2-(2-BROMOPHENYL)ACETOPHENONE
• Synonyms: 2-(2-BROMOPHENYL)-1-PHENYLETHAN-1-ONE;2-(2-BROMOPHENYL)ACETOPHENONE;2-(2-bromophenyl)-1-phenylethanone
• CAS NO: 16897-97-5
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.14
• Mol File: 16897-97-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 371.7°C at 760 mmHg
• Flash Point: 76.4°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 2-(2-BROMOPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-BROMOPHENYL)ACETOPHENONE(16897-97-5)
• EPA Substance Registry System: 2-(2-BROMOPHENYL)ACETOPHENONE(16897-97-5)

Safety Data

• Hazardous Substances Data: 16897-97-5(Hazardous Substances Data)

Usage

Appearance

White solid

Melting point

75-77°C

Usage

Organic synthesis, pharmaceutical research

Common applications

Intermediate in the production of pharmaceutical drugs, reagent in the synthesis of complex organic compounds

Importance

Versatile chemical, key building block for development of new drug candidates and biologically active molecules in pharmaceutical and chemical industries.

InChI:InChI=1/C14H11BrO/c15-13-9-5-4-8-12(13)10-14(16)11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 98-88-4 benzoyl chloride 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 18698-97-0 ortho-bromophenylacetic acid 
• 71-43-2 benzene 
• 16717-64-9 1-azidostyrene 
• 16732-66-4 2-bromophenylhydrazine 
• 177756-64-8 2-(2-bromophenyl)-N-methoxy-N-methylacetamide 
• 100-58-3 phenylmagnesium bromide 
• 95-46-5 2-methylphenyl bromide 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 130089-19-9 1-bromo-2-(2-methoxyethenyl)benzene 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 772339-91-0 α-(o-bromophenylmethyl)-β,β-difluorostyrene 
• 10604-22-5 3-phenylcinnoline 
• 1401421-15-5 5-bromo-3-phenylcinnoline 
• 4809-08-9 3-phenyl-isocoumarin 

Relevant articles and documents

Tailoring the Molecular Properties with Isomerism Effect of AIEgens

It is challenging to achieve precise control on the properties of organic π-functional materials to widen their practical applications. On the other hand, the study of aggregation-induced emission luminogens (AIEgens) helps achieve such goals because of i

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.