169615-68-3

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 41046-67-7 2-iodoresorcinol 
• 108-46-3 recorcinol 
• 514826-78-9 2-iodo-1,3-phenylene bis(trifluoromethanesulfonate) 
• 514826-79-0 3-hydroxy-2-iodophenol trifluoromethanesulfonate 
• 100-39-0 benzyl bromide 
• 108-95-2 phenol 
• 31575-75-4 2-bromophenyl benzyl ether 
• 2678-54-8 ketene diethyl acetal 
• 100-44-7 benzyl chloride 
• 591-20-8 3-Bromophenol 
• 1612240-17-1 5-(benzyloxy)bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-7-ol 
• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 24318-02-3 1-(benzyloxy)-3-chlorobenzene 

Downstream Products

• 1612240-17-1 5-(benzyloxy)bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-7-ol 
• 20289-27-4 7-benzyloxyindole 

Relevant academic research and scientific papers

Catalytic Asymmetric Homologation of Ketones with α-Alkyl α-Diazo Esters

The homologation of ketones with diazo compounds is a useful strategy to synthesize one-carbon chain-extended acyclic ketones or ring-expanded cyclic ketones. However, the asymmetric homologation of acyclic ketones with α-diazo esters remains a challenge due to the lower reactivity and complicated selectivity. Herein, we report the enantioselective catalytic homologation of acetophenone and related derivatives with α-alkyl α-diazo esters utilizing a chiral scandium(III) N,N′-dioxide as the Lewis acid catalyst. This reaction supplies a highly chemo-, regio-, and enantioselective pathway for the synthesis of optically active β-keto esters with an all-carbon quaternary center through highly selective alkyl-group migration of the ketones. Moreover, the ring expansion of cyclic ketones was accomplished under slightly modified conditions, affording a series of enantioenriched cyclic β-keto esters. Density functional theory calculations have been carried out to elucidate the reaction pathway and possible working models that can explain the observed regio- and enantioselectivity.

Skeleton Reorganization of Substituted Benzocyclobutenols through Rh-Catalyzed C-C Bond Cleavage Manipulated by Hydrogen Transfer

Although transition-metal-catalyzed C-C bond activation has been investigated extensively, C-C bond cleavage manipulated by hydrogen transfer has been unexplored. In this work, we disclose a skeleton reorganization of alkene-tethered benzocyclobutenols through Rh-catalyzed C-C bond cleavage coupled with intra- and intermolecular hydrogen transfer. The reaction pathway was well-tuned by the catalytic systems. As a result, divergent benzofurans bearing 4-β-hydroxy or 4-β-keto moieties were synthesized under pH- and redox-neutral conditions.

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

Benzo four-ring derivative as well as preparation method and application thereof in medicine

The invention relates to a benzo tetracyclic derivative as well as a preparation method and medical application thereof, and particularly relates to a benzo tetracyclic derivative shown in a formula (I) or a stereisomer and a pharmaceutically acceptable salt or a predrug thereof, a preparation method thereof, a medicine composition containing the same, and application of a compound or a composition in the field of central nerve. (The formula (I) is shown in the description.).

MODULATORS OF THR-β AND METHODS OF USE THEREOF

Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IlIa, lIIb, IlIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.

Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics

In the present work, a series of structurally novel benzocyclobutene derivatives were identified as general anesthetics through the loss of righting reflex (LORR) experiment on mice. Our initial efforts found compound 1a with a fused four-membered ring on the 2,3-position of the phenol ring could significantly improve the safety profile. Further SAR study revealed that small hydrogen bond acceptor (HBA) groups are optimal for good ED50 along with much broader therapeutic windows, such as compounds 16b and 17. Present work demonstrates the superiority of this novel benzocyclobutene scaffold.

Effect of Ring Functionalization on the Reaction Temperature of Benzocyclobutene Thermoset Polymers

The temperature required to induce cross-linking in typical benzocyclobutene-based thermosets is near 250 °C, which exceeds the use temperature of many chemical components. A new and versatile synthesis of BCB-functionalized monomers has allowed access to monomers that can be incorporated into a variety of macromolecular platforms to enable significantly reduced cure temperatures. Incorporation of BCB-functionalized comonomers in polystyrene and polynorbornene enabled insolublization of thin films by curing at only 120 °C for 1 h.

Concise synthesis of functionalized benzocyclobutenones

A concise approach to access functionalized benzocyclobutenones from 3-halophenol derivatives is described. This modified synthesis employs a [2+2] cycloaddition between benzynes generated from dehydrohalogenation of aryl halides using LiTMP and acetaldehyde enolate generated from n-BuLi and THF, followed by oxidation of the benzocyclobutenol intermediates to provide benzocyclobutenones. The [2+2] reaction can be run on a 10-g scale with an increased yield. A number of functional groups including alkenes and alkynes are tolerated. Coupling of benzynes with ketene silyl acetals to give 8-substituted benzocyclobutenones is also demonstrated.