17078-27-2

Basic information

• Product Name: 4,4'-BIS(DIMETHYLAMINO)BENZIL
• Synonyms: 4,4'-BIS(DIMETHYLAMINO)BENZIL;1,2-DI[4-(DIMETHYLAMINO)PHENYL]ETHANE-1,2-DIONE;1,2-BIS(4-DIMETHYLAMINOPHENYL)-1,2-ETHANEDIONE;1,1'-(1,2-Dioxoethane-1,2-diyl)bis[4-(dimethylamino)benzene];1,2-Bis(p-dimethylaminophenyl)-1,2-ethanedione;1,2-Di[4-(dimethylamino)phenyl]ethanedione;Bis[4-(dimethylamino)phenyl] diketone;4,4'-Bis(dimethylamino)benzil,98%
• CAS NO: 17078-27-2
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.36
• Mol File: 17078-27-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 200-204 °C
• Boiling Point: 437.96°C (rough estimate)
• Flash Point: 206.7°C
• Appearance: Yellow-green to green/Crystalline Powder
• Density: 1.1499 (rough estimate)
• Refractive Index: 1.5700 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.17±0.12(Predicted)
• Stability: Stable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 4,4'-BIS(DIMETHYLAMINO)BENZIL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-BIS(DIMETHYLAMINO)BENZIL(17078-27-2)
• EPA Substance Registry System: 4,4'-BIS(DIMETHYLAMINO)BENZIL(17078-27-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26
• Hazardous Substances Data: 17078-27-2(Hazardous Substances Data)

Usage

Chemical Properties

green cystals

Upstream product

• 79-37-8 oxalyl dichloride 
• 121-69-7 N,N-dimethyl-aniline 
• 60-29-7 diethyl ether 
• 15219-34-8 Oxalyl bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 90-94-8 bis(p-dimethylaminophenyl)methanone 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 59417-06-0 1,4-dimethyl-2,3-dioxopiperazine 
• 62063-67-6 bis(4-dimethylaminophenyl)ethyne 
• 57806-83-4 1,2-bis[4-(dimethylamino)phenyl]-2-hydroxyethanone 
• 21566-11-0 N,N-dimethyl-p-(dimethylamino)benzamide 
• 13190-50-6 4-dimethylaminophenyllithium 
• 54322-62-2 1,2-bis[4-(dimethylamino)phenyl]-1,2-ethanediol 
• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 

Downstream Products

• 90833-70-8 2,3-bis(4-dimethylaminophenyl)-6-quinoxalinecarboxylic acid 
• 90833-33-3 2,3-bis-(4-dimethylaminophenyl)-5-quinoxalinecarboxylic acid 
• 147273-98-1 4,5-bis<4-(N,N-dimethylamino)phenyl>-1H-imidazole-2-thione 
• 335356-27-9 C₂₃H₂₄N₄S 
• 888947-50-0 C₂₂H₂₀N₆ 
• 1268280-20-1 2-{4-[(4-nitrophenyl)ethynyl]phenyl}-4,5-bis[4-(N,N-dimethylamino)phenyl]-1H-imidazole 
• 1268280-18-7 2-(4'-cyanobiphenyl)-4,5-bis[4-(N,N-dimethylamino)phenyl]-1H-imidazole 
• 1268280-19-8 2-(4'-nitrobiphenyl)-4,5-bis[4-(N,N-dimethylamino)phenyl]-1H-imidazole 
• 1268280-21-2 2-{4-[(4-cyanophenyl)ethynyl]phenyl}-4,5-bis[4-(N,N-dimethylamino)phenyl]-1H-imidazole 
• 852107-01-8 C₂₇H₂₆BrN₅ 
• 662150-85-8 C₂₈H₂₉N₅ 

Relevant articles and documents

Diamine preparation for synthesis of a water soluble Ni(II) salen complex

A reliable and efficient synthesis of a Ni(II) salen complex useful in probing nucleic acid structure is described and illustrates a general approach for constructing cis diamines suitable for assembly into N2O2 Schiff base complexes. Two equivalents of an aryllithium reacted with 1,4- dimethylpiperazine-2,3-dione to form the symmetric α-dione. This material was then converted to its dioxime and reduced by TiCl4/NaBH4 to yield the meso-diamine. Condensation of the diamine and salicyladehyde, coordination of nickel and final methylation generated the desired water soluble and redox active complex.

Method for synthesizing benzil derivatives

The invention discloses a method for synthesizing benzil derivatives. The method comprises the steps that a diphenyl acetylene compound, halogenated ammonium salt or iodine chloride and a sulfur source serve as reactants, the reactants react in a solvent for a period of time, purification is conducted, and then the benzil derivatives are obtained. According to the method, a metal catalyst and toxic iodine are not used, the applied reactants are low in price, poisonless and tasteless, the operation method is simple, the yield is high, aftertreatment is easy, and the method is suitable for industrial production.

An effective synthesis of N,N-dimethylamides from carboxylic acids and a new route from N,N-dimethylamides to 1,2-diaryl-1,2-diketones

Carboxylic acids were heated at 150 °C in DMF in the presence of 1.25 equiv of thionyl chloride to give corresponding N,N-dimethylamides in good yields. Tandem chlorination and amidation reactions occurred in the one-pot procedure. Dicarboxylic acids needed prolonged reaction time to produce bisamides in good yields. Some benzamides were efficiently converted into corresponding 1,2-diaryl-1,2-diketones (benzils) under acyloin condensation conditions in the presence of 4,4′-di-tert-butylbiphenyl (DBB) in THF. Ultrasonic irradiation effectively accelerates the reaction, but it is not critical. However, the presence of DBB is fatal to the reaction. Although a few synthetic methods for benzils from benzoic acids have been reported so far, this method is one of the most convenient and highly reproducible procedures.