170798-94-4

Basic information

• Product Name: 1-(benzyloxy)octan-3-ol
• Synonyms: 1-(benzyloxy)octan-3-ol
• CAS NO: 170798-94-4
• Molecular Weight: 236.354
• Mol File: 170798-94-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(benzyloxy)octan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)octan-3-ol(170798-94-4)
• EPA Substance Registry System: 1-(benzyloxy)octan-3-ol(170798-94-4)

Safety Data

• Hazardous Substances Data: 170798-94-4(Hazardous Substances Data)

Upstream product

• 23433-05-8 1,3-octane diol 
• 100-39-0 benzyl bromide 
• 22348-95-4 methyl 3-oxooctanoate 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 70388-33-9 4-benzyloxybut-1-ene 
• 94426-72-9 2-(2-(benzyloxy)ethyl)oxirane 
• 106-97-8 n-butane 
• 19790-60-4 3-Benzyloxypropanal 
• 693-25-4 n-pentylmagnesium bromide 

Downstream Products

• 1311463-07-6 1-(benzyloxy)octan-3-one 
• 1311463-14-5 ((3,3-difluorooctyloxy)methyl)benzene 
• 170798-89-7 1-benzyloxy-3-fluorooctane 

Relevant articles and documents

Regio-selective hydroxylation of gem-difluorinated octanes by alkane hydroxylase (AlkB)

gem-Difluoromethylene substituted molecules constitute a distinct class of fluorinated compounds. In this study, special chemistry has been developed for their preparation based on the highly selective terminal hydroxylation of these gem-difluorinated oct

18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution.

In order to understand the structural features that might lead to an in vivo radiotracer for studying cerebral fatty acid metabolism, 8-[18F]fluorooctanoate derivatives with methyl or gem-dimethyl branching at the C4 position have been prepared. 3-[18F]Fluoro- and 4-[18F]fluorooctanoic acid have also been synthesized for studying the influence of the fluorine position on the in vivo behavior of 18F-labeled octanoic acid analogs. Radiochemical synthesis was achieved by the nucleophilic displacement of a tosylate or mesylate precursor with [18F]fluoride ion. Tissue distribution studies in rats showed low cerebral uptakes of these 18F-labeled fatty acid analogs with poor brain-to-blood ratios. 3-[18F]Fluorooctanoic acid showed considerable defluorination, evident as a high bone activity level. The initial uptake of activity in the brain after injection of ethyl 8-[18F]fluoro-4-methyloctanoate and 4-[18F]-fluorooctanoic acid remained virtually unchanged over an extended time period, similar to that previously observed for the unbranched analogs, ethyl 8-[18F]fluorooctanoate and its free acid. In contrast, the 4-gem-dimethyl branched analog was rapidly and preferentially taken up by the liver. It was shown in the metabolite analysis that labeled metabolites produced from 8-[18F]fluoro-4-methyloctanoic acid were found in blood, and that they could enter the brain to a significant degree. Thus, the present studies showed that radioactivity retention in the brain in the case of the 4-methyl branched analog was mainly attributable to its radioactive metabolites.