17113-31-4

Usage

Uses

Used in Pharmaceutical Industry:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable component in the creation of new drugs and chemical substances, contributing to the advancement of medicinal chemistry.
Used in Research and Development:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a starting material in research for the development of new drugs and chemical substances. Its potential biological activities, including anti-inflammatory and analgesic properties, make it a promising candidate for further exploration and application in the field of drug discovery.
Used in Organic Synthesis:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a key intermediate in organic synthesis, particularly in the preparation of complex organic molecules and compounds. Its reactivity and structural features facilitate the formation of diverse chemical entities, expanding the scope of synthetic chemistry.

Upstream product

• 110-00-9 furan 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 67-56-1 methanol 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 104-94-9 4-methoxy-aniline 
• 196952-70-2 1-(4-methoxyphenyl)buta-2,3-dien-1-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 733-53-9 p-methoxyphenyl(phenyl)iodonium tetrafluoroborate 
• 118486-94-5 2-(tributylstannyl)furan 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 6165-76-0 propargyl p-toluenesulfonate 
• 106-96-7 propargyl bromide 
• 623-12-1 4-chloromethoxybenzene 
• 408492-37-5 2-(n-butyltellanyl)furan 

Downstream Products

• 1230-48-4 2,5-Bis(4-methoxyphenyl)furan 
• 126739-60-4 2-(4′-methoxyphenyl)-5-(4′-nitrophenyl)furan 
• 72310-69-1 2-(5-<4-methoxy>phenyl-2-furyl)ethanol 
• 17113-34-7 dimethyl 3-hydroxy-6-(4-methoxyphenyl)phthalate 
• 20842-13-1 1-(4-Methoxy-phenyl)-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid dimethyl ester 
• 188483-26-3 3-bromo-2-(4-methoxyphenyl)-5-(4-nitrophenyl)furan 
• 60112-44-9 5-(4-methoxyphenyl)furan-2(3H)-one 
• 34070-33-2 5-(4-methoxyphenyl)furan-2-carbaldehyde 
• 94540-81-5 2-(4-methoxyphenyl)-5-phenylfuran 
• 1376960-39-2 2-(4-fluorophenyl)-5-(4-methoxyphenyl)furan 
• 1421046-03-8 C₁₁H₉IO₂ 
• 1421046-04-9 2-(4-trifluoromethylphenyl)-5-(4-methoxyphenyl)furan 
• 144774-54-9 (Z)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4-dione 
• 1421046-05-0 C₁₉H₁₂F₆O₂ 

Relevant academic research and scientific papers

Efficient procedure for the preparation of 2-bromofuran and its application in the synthesis of 2-arylfurans

A simple, straightforward, and scalable procedure for the preparation of 2-bromofuran using N-bromosuccinimide (NBS) in dimethylformamide (DMF) is reported. The described preparation is conducted on a 20 to 50g scale and does not require extractive workup procedures or chromatographic purifications. To illustrate the synthetic applications of 2-bromofuran, palladium-catalyzed Suzuki coupling reactions of the prepared 2-bromofuran with various aryl boronic acids were investigated, and moderate to good yields of 2-arylfurans were obtained. Copyright Taylor & Francis Group, LLC.

Cross-Coupling Reactions for the Preparation of 2-Arylfurans, 2-Benzylfuran and 2-Cinnamylfuran

Pd catalysed coupling between organyl bromides and either 2-lithofuran or 2-furylzinc chloride are described.Arylation by a wide variety of aromatic bromides can be carried out in high yields and on a large scale.Benzylation and cinnamylation are also

Fabrication of Graphitic Carbon Nitride-Based Film: An Emerged Highly Efficient Catalyst for Direct C—H Arylation under Solar Light

Photoredox C—H bond formation can proceed in aerobic environment under solar light and has therefore become attractive. Nowadays, different types of expensive novel metal complexes and nanomaterials have been urbanized as photocatalysts for direct C—H bon

Pyrazole-Mediated C-H Functionalization of Arene and Heteroarenes for Aryl-(Hetero)aryl Cross-Coupling Reactions

Herein we introduce a transition-metal-free protocol that involves a commercially available, inexpensive pyrazole molecule to conduct C-C cross-coupling reactions at room temperature via a radical pathway. Using this method, an aryldiazonium salt has been coupled to a wide range of arenes and heteroarenes including benzene, mesitylene, thiophene, furan, benzoxazole to result the corresponding biaryl products. The full reaction mechanism is elucidated along with the crystallographic probation of an active initiator species. A potassium-stabilized deprotonated pyrazole steers single-electron transfer to the substrate and behaves as an initiator for the reaction.

Synthesis method of monosubstituted or disubstituted furan derivatives

The invention relates to the field of medicine synthesis, and provides a synthesis method of monosubstituted or disubstituted furan derivatives, wherein the synthesis method can be used for synthesizing various furan derivatives with different substituent groups and has high flexibility. According to the synthesis method of the monosubstituted or disubstituted furan derivatives, 5-hydroxymethyl-[delta]2-isoxazoline derivative is used as a raw material in an acidic solvent, and the monosubstituted or disubstituted furan derivatives are synthesized in one step under the action of a metal reducing agent; and according to the method, the furan derivatives with different substituent groups can be synthesized by adopting the 5-hydroxymethyl-[delta]2-isoxazoline derivatives with different substituent groups, high flexibility is achieved, the technical scheme is simple in step and mild in reaction condition, synthesis of the furan derivatives can be achieved through a one-pot method, the reaction yield is high, and large-scale production is facilitated.

Pd Nanoparticles Embedded Into MOF-808: Synthesis, Structural Characteristics, and Catalyst Properties for the Suzuki–Miyaura Coupling Reaction

Abstract: A heterogeneous single-site catalyst Pd@MOF-808 was successfully synthesized by water-based, green synthesis procedure. The catalytic experiments exhibited the Pd@MOF-808 promoted efficiently the Suzuki–Miyaura coupling reaction without the assistance of organic phosphine ligands at atmospheric pressure conditions. The catalyst also could be applied in the gram-scale synthesis of industrially anti-inflanmatory analgestic Fenbufen. Graphic Abstract: [Figure not available: see fulltext.]

Pd-NHCs Enabled Suzuki-Miyaura Cross-Coupling of Arylhydrazines via C–N Bond Cleavage

We describe a highly efficient protocol for cross-coupling of phenylhydrazines with arylboronic acids by Pd-NHCs under aerobic reaction condition. A series of well-defined Pd-NHCs complexes were evaluated and the relationship between the structure and the catalytic properties was investigated. It was disclosed that the Pd-PEPPSI-IPr proved to be the robust precatalyst, providing access to a range of (hetero)biaryls in good to excellent yields.

New Nickel-Based Catalytic System with Pincer Pyrrole-Functionalized N-Heterocyclic Carbene as Ligand for Suzuki-Miyaura Cross-Coupling Reactions

A new catalytic system with Ni(NO3)2·6H2O as the catalyst and a pincer pyrrole-functionalized N-heterocyclic carbene as the ligand was employed in the Suzuki-Miyaura cross-coupling reactions of aryl iodides with arylboronic acids. With 5 mol% catalyst, the catalytic reactions proceeded at 160 °C, giving coupling products in isolated yields of up to 94% in short reaction times (1-4 h). The system worked efficiently with aryl iodides bearing electron-donating or electron-withdrawing groups and arylboronic acids with electron-donating groups. Steric effects were observed for both aryl iodides and arylboronic acids. It is proposed that the reactions underwent a Ni(I)/Ni(III) catalytic cycle.

σ-Bond initiated generation of aryl radicals from aryl diazonium salts

σ-Bond nucleophiles and molecular oxygen transform aryl diazonium salts into aryl radicals. Experimental and computational studies show that Hantzsch esters transfer hydride to aryl diazonium species, and that oxygen initiates radical fragmentation of the diazene intermediate to produce aryl radicals. The operational simplicity of this addition-fragmentation process for the generation of aryl radicals, by a polar-radical crossover mechanism, has been illustrated in a variety of bond-forming reactions.

ORGANIC SEMICONDUCTING MATERIAL AND ITS SYNTHESIS AND ORGANIC SEMICONDUCTING COMPONENT WITH THE MATERIAL

New absorbing materials of formula (I) for use in organic semiconducting components: