17241-04-2Relevant articles and documents
Reductive α-substitution of sulfoxides with grignard reagents promoted by a magnesium amide
Kobayashi, Kazuhiro,Yokota, Kouichi,Akamatsu, Hideki,Morikawa, Osamu,Konishi, Hisatoshi
, p. 441 - 443 (1996)
The reactions of sulfoxides bearing α-hydrogen(s) (RSOCHR1R2: R-alkyl or aryl; R1, R2 = H, alkyl, or aryl) with Grignard reagents (R3MgBr: R3 = Et, Ph, or vinyl) in the presence of the diisopropylaminomagnesium reagent, generated in situ by the treatment of diisopropylamine with the appropriate Grignard reagents in diethyl ether, have resulted in the formation of the corresponding sulfides (RSCR1R2R3) in moderate to good isolated yields.
A highly efficient heterogeneous rhodium(I)-catalyzed C-S coupling reaction of thiols with polychloroalkanes or alkyl halides under mild conditions
Xia, Jianhui,Yao, Ruiya,Cai, Mingzhong
, p. 221 - 225 (2015)
Heterogeneous C-S coupling reaction of thiols with polychloroalkanes or alkyl halides was achieved at 30 or 80 °C in the presence of 5 mol% of an MCM-41-immobilized bidentate phosphine rhodium complex (MCM-41-2P-RhCl(PPh3)) and triethylamine, yielding a variety of formaldehyde dithioacetals, ethylenedithioethers and unsymmetric thioethers in good to excellent yields. This heterogeneous rhodium catalyst can be easily recovered and recycled by simple filtration of the reaction solution and used for at least 10 consecutive trials without significant loss of activity.
A NOVEL AND CONVENIENT SYNTHESIS OF BISMETHANES
Campbell, Malcolm M.,Jigajinni, Veerappa B.,MacLean, Keith A.,Wightman, Richard H.
, p. 3305 - 3306 (1980)
Bismethanes are produced in high yield on treatment of aryl chloromethyl sulphides with neutral alumina.
Preparation method of dithioacetal derivative
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Paragraph 0017-0019, (2021/02/10)
The invention discloses a method for preparing a dithioacetal derivative, which specifically comprises the steps of sequentially adding sodium borohydride and thiophenol or mercaptan into a reaction tube filled with a dichloromethane solvent, sealing the
Sc(OTf)3-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source
Dethe, Dattatraya H.,Shukla, Manmohan,Dherange, Balu D.
supporting information, p. 5778 - 5782 (2020/07/30)
Use of nitromethane as an electrophilic methylene source for the synthesis of symmetrical dithioacetals and bisarylmethanes has been showcased using Sc(OTf)3 as a catalyst. The procedure allows straightforward access to the densely functionalized dithioacetals and bisarylmethanes under mild conditions. Additionally, the method has been applied for the synthesis of antimalarial tetramethyl mellotojaponin C and anticancer dimeric phloroglucinol derivative.
Reduction of CO2 with NaBH4/I2 for the Conversion of Thiophenols to Aryl Methyl Sulfides
Zhang, Bo,Fan, Zhengning,Guo, Zhiqiang,Xi, Chanjuan
, p. 8661 - 8667 (2019/07/03)
We report a tandem reaction to realize reduction of carbon dioxide with thiophenols to generate aryl methyl sulfides under the NaBH4/I2 system with 18-crown-6 as the solvent. Thiophenols bearing electron-donating and electron-withdrawing groups are feasible in this reaction. Controlled experiment results indicate that 18-crown-6 plays a critical role in six-electron reduction of carbon dioxide.
A thioether compound and its synthetic method and application (by machine translation)
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Paragraph 0050; 0051; 053, (2018/12/02)
The invention belongs to the technical field of sulfur-containing organic synthesis, discloses a thioether compound and its synthetic method and application. The vinyl ether compound is acetone, b of sulfur compounds, inorganic alkali and 18 - crown ether - 6 mixing, heating and stirring, in the inorganic alkali under the action of the catalyst, the reaction under air atmosphere, and then concentrated, purified made, the vinyl ether compound of molecular formula as formula (1) as shown: Wherein R1 And R2 Selected from hydrogen atom, alkyl, alkoxy, nitro, amino, hydroxy, halogen base, acyl, aryl or a heterocyclic group. The method can avoid the toxicity is relatively large of the methylene chloride and halogenated hydrocarbon such as methylene diiodide. The synthesis step is simple, convenient and easy operation, environment friendly and under a comparatively mild condition, have high conversion, the yield of the product can be as high as 96%. The thioether compound can be applied to the production of organic synthetic intermediates in the field. (by machine translation)
Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source
Chen, Qian,Yu, Guodian,Wang, Xiaofeng,Huang, Yulin,Yan, Yan,Huo, Yanping
supporting information, p. 4086 - 4089 (2018/06/12)
An efficient halogen-free Cs2CO3-promoted methylene insertion into disulfide bonds has been achieved using acetone as a methylene source under mild conditions. This method provides a convenient and practical route to dithioacetals in up to 96% yield with good functional group compatibility.
Reduction of CO2 into Methylene Coupled with the Formation of C-S Bonds under NaBH4/I2 System
Guo, Zhiqiang,Zhang, Bo,Wei, Xuehong,Xi, Chanjuan
supporting information, p. 6678 - 6681 (2018/10/24)
A selective four-electron reduction of CO2 with thiophenol using NaBH4 as a reductant is described to access dithioacetals. This reaction provides a novel synthetic method for the highly selective conversion of CO2 into methylene, and a new access to molecular structures via formation of C-S bonds using CO2 as the C1 source.
An expeditious and efficient bromomethylation of thiols: Enabling bromomethyl sulfides as useful building blocks
Silva-Cuevas, Carolina,Paleo, Ehecatl,León-Rayo, David F.,Lujan-Montelongo, J. Armando
, p. 24654 - 24659 (2018/07/25)
A facile and highly efficient method for the bromomethylation of thiols, using paraformaldehyde and HBr/AcOH, has been developed, which advantageously minimizes the generation of highly toxic byproducts. The preparation of 22 structurally diverse α-bromomethyl sulfides illustrates the chemo-tolerant applicability while bromo-lithium exchange and functionalization sequences, free radical reductions, and additions of the title compounds demonstrate their synthetic utility.
