173424-77-6 Usage
General Description
Cloretazine, also known as laromustine, is an investigational chemotherapeutic agent that has shown promising results in the treatment of various types of cancer, including leukemia, lymphoma, and solid tumors. It works by targeting and inhibiting the DNA of cancer cells, leading to cell death. Cloretazine is a prodrug, meaning it is inactive until it is activated in the body to release its active form. It has been studied in both adult and pediatric populations and has demonstrated efficacy in combination with other chemotherapy agents, as well as in patients with relapsed or refractory disease. However, further clinical trials are needed to fully establish its safety and effectiveness.
Check Digit Verification of cas no
The CAS Registry Mumber 173424-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,4,2 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 173424-77:
(8*1)+(7*7)+(6*3)+(5*4)+(4*2)+(3*4)+(2*7)+(1*7)=136
136 % 10 = 6
So 173424-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)
173424-77-6Relevant articles and documents
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
Shyam, Krishnamurthy,Penketh, Philip G.,Loomis, Regina H.,Rose, William C.,Sartorelli, Alan C.
, p. 796 - 801 (1996)
Several 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydr azi nes were synthesized and primarily evaluated for antitumor activity against the murine L1210 leukemia. All of the compounds tested were capable of producing "cures" of mice bearin
