17355-75-8Relevant articles and documents
Synthesis and Biological Screening of Novel 5-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole Derivatives
Agrawal, Brijmohan R.,Farooqui, Mazahar,Khandebharad, Amol U.,Kulkarni, Pravin S.,Sarda, Swapnil R.
, p. 209 - 215 (2022/01/06)
A new series of 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole (6a-o) have been synthesized by a cyclocondensation reaction of ethyl 5-(4-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (3a-c) with aryl imidoxime (5a-e). The newly synthesize
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
Aghazadeh Tabrizi, Mojgan,Baraldi, Pier Giovanni,Baraldi, Stefania,Ruggiero, Emanuela,De Stefano, Lucia,Rizzolio, Flavio,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Chicca, Andrea,Lapillo, Margherita,Gertsch, Jürg,Manera, Clementina,Macchia, Marco,Martinelli, Adriano,Granchi, Carlotta,Minutolo, Filippo,Tuccinardi, Tiziano
, p. 1340 - 1354 (2018/02/17)
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes. Beyond the possible utilization of MA
A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxophosphonates
Sun, Aixue,Ye, Jia-Hai,Yu, Haitao,Zhang, Wenchao,Wang, Xiaolong
supporting information, p. 889 - 892 (2015/03/03)
A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles has been developed by reacting of hydrazonoyl halides with β-oxophosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility has been established.