17355-75-8

Usage

Belongs to the pyrazole family

1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-, ethyl ester is part of a group of organic compounds that contain a five-membered ring with one nitrogen atom.

Ester derivative

1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-, ethyl ester is formed by the esterification of the carboxylic acid group of 1,5-diphenyl-1H-pyrazole-3-carboxylic acid with ethanol.

Applications in organic synthesis, drug development, and material science

1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-, ethyl ester may be used as a building block or intermediate in the synthesis of more complex molecules, or as a potential drug candidate due to its biological activity.

Specific properties and potential uses depend on its synthesis and purification

The properties and potential uses of 1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-, ethyl ester may vary depending on the method of synthesis and the degree of purity achieved.

Proper handling and safety precautions

As with any chemical compound, it is important to handle 1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl, ethyl ester with care and follow appropriate safety protocols to minimize the risk of exposure or accidents.

Upstream product

• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 100-63-0 phenylhydrazine 
• 88330-82-9 ethylbenzoylpyruvate sodium salt 
• 931-55-5 phenyl-diazene 
• 64-17-5 ethanol 
• 59-88-1 phenylhydrazine hydrochloride 
• 100-34-5 benzene diazonium chloride 
• 472800-84-3 ethyl (3Z)-4-hydroxy-2-oxo-4-phenylbut-3-enoate 
• 88330-79-4 ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate 
• 907178-38-5 (E)-2-(N-methoxy-N-methyl-amino)-4-oxo-4-phenyl-2-butenoic acid ethyl ester 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 623-47-2 propynoic acid ethyl ester 
• 98-86-2 acetophenone 
• 3815-83-6 3,4-diphenylsydnone 

Downstream Products

• 13599-22-9 1,5-diphenylpyrazole-3-carboxylic acid 
• 945984-78-1 (1,5-diphenyl-1H-pyrazol-3-yl)-methanol 
• 1428261-49-7 C₃₂H₄₅N₃O 
• 1428261-50-0 C₂₁H₂₂N₄O 

Relevant academic research and scientific papers

Synthesis and Biological Screening of Novel 5-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole Derivatives

A new series of 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole (6a-o) have been synthesized by a cyclocondensation reaction of ethyl 5-(4-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (3a-c) with aryl imidoxime (5a-e). The newly synthesize

La(OTf)3-catalysed one-pot synthesis of pyrazole tethered imidazo[1,2-: A] azine derivatives and evaluation of their light emitting properties

A facile and efficient protocol has been unfolded towards the diversity-oriented synthesis of highly fluorescent pyrazole C-3(5) tethered imidazo[1,2-a]azines via an La(OTf)3 catalysed one-pot multicomponent assembly of pyrazole carbaldehydes, 2-aminoazines and isonitriles. This present protocol offers several advantages such as multiple bond formation in a single step, low catalyst loading, short reaction time, appreciable atom economy, good functional group tolerance, scalability and easy to perform reaction conditions. The optical properties of pyrazolyl imidazo[1,2-a]azines were also studied, and they exhibited an excellent fluorescence quantum yield (ΦF up to 83%).

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes. Beyond the possible utilization of MA

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.

A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxophosphonates

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles has been developed by reacting of hydrazonoyl halides with β-oxophosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility has been established.

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxophosphonates

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles has been developed by reacting of hydrazonoyl halides with β- oxophosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility has been established.

Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21

Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant-fatty acid amide analogues have been prepared. Synthesis of pyrazoles 2a-2c was achieved by a two steps simple methodology via α,β-unsaturated ketones. Carboxamides 8a-8h were obtained in good yields from esters 7a-7c by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic agents. Some of them showed interesting properties reducing food intake in rats by a mechanism which does not involve the endocannabinoid system.

'One-pot' synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction

A concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates.

Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles

Bromodifluoromethyl substituted β-diketone 3a-3d, prepared from corresponding ketones and ethyl bromodifluoroactate in the presence of sodium methoxide, reacted with aryl hydrazine derivatives affording bromodifluoromethyl substituted pyrazoles in high re