17395-99-2Relevant articles and documents
Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment
de Melo, Thais Regina Ferreira,Dulmovits, Brian,Fernandes, Guilherme Felipe dos Santos,de Souza, Cristiane M.,Lanaro, Carolina,He, Minghzu,Al Abed, Yousef,Chung, Man Chin,Blanc, Lionel,Costa, Fernando Ferreira,dos Santos, Jean Leandro
, (2021)
Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide–nitric oxide (NO) donor derivatives (3a–f) and evaluated their suitability as novel HbF in
METHODS FOR THE TREATMENT OF OBESITY USING APREMILAST
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, (2019/05/22)
Methods of treating, managing or preventing obesity and overweight are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.
HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
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Page/Page column 221; 222, (2017/12/02)
This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) ("Degrons"), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.
