175838-98-9

Basic information

• Product Name: 4-DIFLUOROMETHOXY-BIPHENYL
• Synonyms: 4-DIFLUOROMETHOXY-BIPHENYL
• CAS NO: 175838-98-9
• Molecular Formula: C13H10F2O
• Molecular Weight: 220.21
• Mol File: 175838-98-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 296.694°C at 760 mmHg
• Flash Point: 140.849°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 4-DIFLUOROMETHOXY-BIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIFLUOROMETHOXY-BIPHENYL(175838-98-9)
• EPA Substance Registry System: 4-DIFLUOROMETHOXY-BIPHENYL(175838-98-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 175838-98-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10F2O/c14-13(15)16-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13H

Upstream product

• 92-69-3 4-Phenylphenol 
• 150542-06-6 α,α,α-iodinefluoroacetophenone 
• 354-08-5 bromodifluoroacetic acid 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 
• 235416-44-1 1,1'-biphenyl-4-yl formate 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 75-46-7 trifluoromethan 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 89264-09-5 1-(3-chloro-1,1,3,3-tetrafluoroprop-1-en-2-yl)-4-methylbenzene 
• 774-29-8 2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone 
• 1321028-39-0 2-chloro-2,2-difluoro-1-(4-(trifluoromethyl)phenyl)ethanone 
• 1321028-38-9 2-chloro-1-(4-(dimethylamino)phenyl)-2,2-difluoroethanone 
• 1321028-35-6 2-chloro-2,2-difluoro-1-(4-fluorophenyl)ethanone 
• 1321028-33-4 C₈H₄Cl₂F₂O 

Relevant articles and documents

Study on the mild, rapid and selective difluorocarbene-mediated triclassification of iododifluoroacetophenone with secondary amines and tree model for product classification

Difluorocarbene is a very active and widely used intermediate in organic synthesis. In this work, a room temperature difluorocarbene-mediated triclassification reaction of iododifluoroacetophenone (2) and secondary amines with mild condition, short reaction time (only 10 min) and high selectivity had been studied, which produced one of the following three substances: N-CF2H derivatives (up to 87% yield), formamides (82–89% yield) or the recycled starting secondary amines. This phenomenon was related to the structural stability of the corresponding products. If unstable, it would be hydrolyzed to formamides first, and then further hydrolyzed to starting amines. Based on the geometric structure of the raw materials, the corresponding prediction tree model was established, which provided guidance for the further application of difluoromethylation of Vemurafenib (1ee) and AZD9291 (1ff).

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

A simple and efficient visible-light photoredox one-pot method for difluoromethylation of phenols and thiophenols has been developed. The protocol uses commercially available, inexpensive, and easy handling difluorobromoacetic acid as the difluoromethylating agent, and the diverse O- and S-difluoromethylated products were prepared in good yields with tolerance of many functional groups.

18F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [18F]Fluoride

We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F-fluorination of aryl-OCHFCl, -OCF2Br and -SCF2Br precursors under mild conditions. This AgI-mediated process allows for the first time access to a range of 18F-labeled aryl-OCHF2, -OCF3 and -SCF3 derivatives, inclusive of [18F]riluzole. The 18F-labeling of these medicinally important motifs expands the radiochemical space available for PET applications. A halogen exchange (halex) 18F-fluorination process offers access for the first time to 18F-labeled arylOCF3, arylOCHF2 and arylSCF3, three motifs of established medicinal importance in PET radiotracers. The use of silver(I) triflate is critical to permit 18F-labeling under mild conditions.