17640-23-2Relevant articles and documents
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis
Carroll, Brian J.,Moss, Steven J.,Bai, Linquan,Kato, Yasuo,Toelzer, Sabine,Yu, Tin-Wein,Floss, Heinz G.
, p. 4176 - 4177 (2002)
The unusual "glycolate" extender unit at C-9/C-10 of ansamitocin is not derived from 2-hydroxymalonyl-CoA or 2-methoxymalonyl-CoA, as demonstrated by feeding experiments with the corresponding 1-13C-labeled N-acetylcysteamine thioesters but is formed from an acyl carrier protein (ACP)-bound substrate, possibly 2-methoxymalonyl-ACP, elaborated by enzymes encoded by a subcluster of five genes, asm12-17, from the ansamitocin bisosynthetic gene cluster. Copyright
Improved ester interchange catalysts
Kissling, Rebecca M.,Gagne, Michel R.
, p. 4209 - 4212 (2007/10/03)
(equation presented) Mixed alkoxide/aryloxide clusters are long-lived and milder than previously reported ester interchange catalysts. They completely transform difficult substrates in a single synthetic operation with lower catalyst and reagent ester loadings. In addition to superior activities, these mixed clusters are kinetically less basic toward enolizable esters.
