17788-47-5Relevant academic research and scientific papers
Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4-Naphthoquinones
Bao, Na,Ou, Jinfeng,Shi, Wei,Li, Na,Chen, Li,Sun, Jianbo
, p. 2254 - 2258 (2018)
A platform of highly efficient synthetic methodologies has been established to access a focused library of substituted 1,4-naphthoquinones derivatives functionalized with a diversity of amino/hydroxy/alkyl groups. Furthermore, the structure–activity relationship deduced from antiproliferative activities and toxicities of this 1,4-naphthoquinone library and intracellular reactive oxygen species (ROS) level detections might warrant future potential of plumbagin (2) and compound 13 as promising basic structures to develop novel anti-cancer agents.
Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds
da Silva Júnior, Eufranio N.,de Carvalho, Renato L.,Almeida, Renata G.,Rosa, Luisa G.,Fantuzzi, Felipe,Rogge, Torben,Costa, Pedro M. S.,Pessoa, Claudia,Jacob, Claus,Ackermann, Lutz
supporting information, p. 10981 - 10986 (2020/07/13)
Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step-economical access to valuable quinones with a wide range of applications. C?H/N?H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity.
Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols
Jiang, Jia-Heng,Boominathan, Siva Senthil Kumar,Hu, Wan-Ping,Chen, Chung-Yu,Vandavasi, Jaya Kishore,Lin, Ying-Ting,Wang, Jeh-Jeng
, p. 2284 - 2289 (2016/05/19)
A sequential one-pot approach towards arylated benzoquinones and naphthoquinones is reported. The reaction proceeds through oxidation of phenols/naphthols followed by CH-arylation with a catalytic amount of triflic acid. Preliminary cytotoxic studies were carried out with five different cell lines and some of the compounds show promising activity. This one-pot approach towards arylated benzoquinones and naphthoquinones proceeds through oxidation of phenols/naphthols followed by CH-arylation. Preliminary cytotoxic studies for some of the compounds showed promising activity.
1,2-Naphthoquinone-based Derivatives and and Methods for Preparing them
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Paragraph 0355-0360, (2016/11/24)
The present invention relates to a compound represented by chemical formula (1), a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, a tautomer, an enantiomer, or a pharmaceutically acceptable diastereomer thereof, a preparing method thereof, and a medical composition having a treating or preventing effect of metabolic diseases containing the same. Here, R_1 to R_3, and X_1 to X_6 are the same as defined in a first claim.COPYRIGHT KIPO 2015
Metal-free cycloaddition to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-diones
Chen, Ping-Fan,Kuo, Kung-Kai,Vandavasi, Jaya Kishore,Boominathan, Siva Senthil Kumar,Chen, Chung-Yu,Wang, Jeh-Jeng
supporting information, p. 9261 - 9266 (2015/09/07)
A metal-free domino [3 + 2] cycloaddition is reported to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives and provide an alternative approach to the azide-alkyne cycloadditions. The key features are easily available starting materials, mild reaction conditions, a good atom economy, eco-friendly characteristics and a broad substrate scope with high yields.
Vicinal acetylenic derivatives of 2-amino-1,4-naphthoquinone as key precursors of heterocyclic quinones
Shvartsberg,Kolodina,Lebedeva,Fedenok
, p. 582 - 588 (2013/05/09)
The Pd-catalyzed reaction between 3-acetylamino-2-bromo-1,4-naphthoquinones and CuI acetylides prepared in situ gave 3-acetylamino-2-alkynyl-1, 4-naphthoquinones, which were transformed into benz[f]indole-4,9-dione and benzo[g]quinoline-5,10-dione derivatives.
Synthesis of benz[f]indole-4,9-diones via acetylenic derivatives of 1,4-naphthoquinone
Shvartsberg, Mark S.,Kolodina, Ekaterina A.,Lebedeva, Nadezhda I.,Fedenok, Lidiya G.
scheme or table, p. 6769 - 6771 (2010/04/27)
A synthetic route to benz[f]indole-4,9-diones from 1,4-naphthoquinone is described. Effective methods for cross-coupling of 3-acetylamino-2-bromo-1,4-naphthoquinone with terminal acetylenes and cyclization of the resulting 3-acetylamino-2-alkynyl-1,4-naphthoquinones are developed.
Efficient synthesis of the tetracyclic aminoquinone moiety of marmycin A
Maugel, Nathan,Snider, Barry B.
supporting information; experimental part, p. 4926 - 4929 (2010/01/16)
An efficient four-step route to the tetracyclic aminoquinone moiety of marmycin A that proceeds in 41% overall yield from 5-nitronaphthoquinone and 5-methy 1-1-vinylcyclohexene will facilitate preparation of marmycin A analogues for biological evaluation.
Process for producing 1-aminoanthraquinones
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, (2008/06/13)
A process for producing 1-aminoanthraquinones represented by the formula (C) STR1 wherein R1 and R2, independently from each other, denote one type selected from a hydrogen atom, an alkyl group having 1 to 4 carbon atoms and a halogen atom, which comprises converting 5-nitro-1,4,4a,9a-tetrahydroanthraquinones respresented by formula (A) STR2 wherein R1 and R2 are as defined above, into 1-hydroxylaminoanthraquinones represented by formula (B) STR3 wherein R1 and R2 are as defined above, in the presence of a basic compound, and electrolytically reducing the resulting 1-hydroxylaminoanthraquinones in the presence of a basic compound.
