17953-46-7

Upstream product

• 166948-12-5 3-diethylamino-5-methyl-4-phenylisothiazole 1,1-dioxide 
• 100-52-7 benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 
• 98-88-4 benzoyl chloride 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 591-50-4 iodobenzene 
• 14182-01-5 (2E)-2-methyl-1,3-diphenylprop-2-en-1-one 
• 106471-21-0 2-methyl-1,3-diphenyl-propane-1,3-diol 
• 908094-04-2 phenyldiazomethane 
• 64-17-5 ethanol 
• 1846-29-3 1,3-diphenyl-2-methylpropane-1,3-dione 
• 302-01-2 hydrazine 

Downstream Products

• 92670-70-7 2-<1-(3,5-diphenyl-4-methylpyrazolyl)>-1,4-diphenylbut-2-ene-1,4-dione 
• 1204746-22-4 2-{(4-Methyl-3,5-diphenyl-1H-pyrazol-1-yl)methyl}thiazole-4-carboxylic acid 
• 1204746-13-3 ethyl 2-(4-methyl-3,5-diphenyl-1H-pyrazol-1-yl)thiazole-4-carboxylate 
• 1204746-21-3 2-{2-(4-methyl-3,5-diphenyl-1H-pyrazol-1-yl)thiazol-4-yl}acetic acid ethyl ester 
• 1204746-20-2 5-(4-methyl-3,5-diphenyl-1H-pyrazol-1-yl)picolinic acid methyl ester 
• 1204746-38-2 2-(4-methyl-3,5-diphenyl-1H-pyrazol-1-yl)thiazole-4-carboxylic acid 
• 1204747-45-4 C₂₂H₁₇N₃O₂ 
• 1204747-44-3 C₂₁H₁₆N₂O₂S 
• 1204747-43-2 C₂₁H₁₇N₃O₂S 

Relevant academic research and scientific papers

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists

We describe a medicinal chemistry approach to generate a series of 2-(1H-pyrazol-1-yl)thiazole compounds that act as selective EP1 receptor antagonists. The obtained results suggest that compound 12 provides the best EP1 receptor ant

DABCO-promoted synthesis of pyrazoles from tosylhydrazones and nitroalkenes

An efficient synthesis of pyrazoles from tosylhydrazones and nitroalkenes was developed. In comparison with the previously reported 1,3-dipolar cycloaddition reaction of diazo compounds with electron-deficient alkenes or alkynes, this methodology proceeded with a sequential Baylis-Hillman/ intramolecular cyclization mechanism and a variety of reversed regioselectivity products were prepared in good yields.

Palladium-catalyzed carbonylative α-arylation for accessing 1,3-diketones

With a hint of CO: The first Pd-catalyzed carbonylative α-arylations of simple ketones with carbon monoxide is presented for the direct synthesis of 1,3-diketones (see scheme). The method uses only stoichiometric amounts of CO, and hence allows for the si

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS

Nitrogen-containing heterocyclic compounds represented by the following Formula (1) are provided. The compounds or salts thereof have a strong EP1 antagonistic activity when they are administered to a human or an animal, and they are useful as an effective component of a pharmaceutical agent for prophylaxis and/or treatment of an overactive bladder, for example. Furthermore, they are useful as an effective component of a pharmaceutical agent for the prophylaxis and/or treatment of symptoms including frequent urination, urinary urgency and urinary incontinence.

Isothiazoles. Part 3. Cycloadditions of Diazoalkanes to 3-Dialkylaminoisothiazole 1,1-Dioxides. Competitive Ring Cleavage in 3a,4-Dihydro-6aH-pyrazoloisothiazole 1,1-Dioxides: Formation of 2-Thia-3-azabicyclohex-3-ene 2,2-Dioxides and/or Pyrazoles

3-Dialkylaminoisothiazole 1,1-dioxides 1 readily undergo cycloadditions with diazoalkanes 2.The reaction is characterized by high site- and regio-selectivity.Cycloadducts 3 and 4 were found to undergo straightforward thermolysis reactions at elevated temperature through two different paths characterized respectively by loss of nitrogen or sulfur dioxide and diethylcyanamide.The different transformations affording pyrazoles 6 and derivatives of the new heterocycle 2-thia-3-azabicyclohex-3-ene 2,2-dioxide 5 are discussed.

Catalytic dehydrogenation process for the preparation of 3,4,5-trisubstituted pyrazoles

There is provided a process for the preparation of 3,5-disubstituted pyrazoles which involves: A. the reaction of a methyl ketone, such as acetophenone or an appropriate derivative thereof, with an appropriate aldehyde, such as benzaldehyde in the presence of base to form a 1,3-disubstituted α,β-unsaturated ketone, such as chalcone or a substituted chalcone, B. the acidification of said α,β-unsaturated ketone, followed by treatment of the acidified reaction mixture with hydrazine to form a disubstituted pyrazoline, and C. the catalytic dehydrogenation of said pyrazoline to yield the desired 3,5-disubstituted pyrazole.