17989-94-5Relevant academic research and scientific papers
Benzene Alkylation with Cycloolefins under the Action of [Et3NH]+[Al2Cl7]? Ionic Liquid
Aminov,Mazitova,Khusnutdinov
, p. 2171 - 2177 (2020/01/08)
Benzene alkylation with mono- and bicyclic olefins under the action of an inorganic ionic liquid [Et3NH]+[Al2Cl7]? with the formation of benzene cycloalkyl derivatives in 58–98% yield has been performed for the first time. It has been found that the increase in the olefin cycle size improves the selectivity with respect to monocycloalkyl derivatives.
Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis: Via phosphine free remote group directed hydroarylation
Ruffoni, Alessandro,Ferri, Nicola,Pinto, Andrea,Pellegrino, Sara,Contini, Alessandro,Clerici, Francesca
supporting information, p. 310 - 314 (2019/03/08)
A phospine free hydroarylation reaction applied to norbornene derivatives is described for the first time and was exploited for the regioselective gram scale synthesis of AR-148, a known Rac1-Tiam1 PPI inhibitor. Umpolung conversion of the nitro group int
Hydrotalcite-supported palladium nanoparticles as catalysts for the hydroarylation of carbon-carbon multiple bonds
Di Nicola,Arcadi,Gallucci,Mucciante,Rossi
supporting information, p. 1952 - 1957 (2018/02/09)
Palladium nanoparticles supported on Mg/Ca hydrotalcites catalyze the hydroarylation reaction of different alkynes and alkenes with aryl iodides under air in MeCN. The reaction of tertiary propargylic alcohols (1) with aryl iodides (2) yields, stereoselectively, γ,γ-diarylallylic alcohols (3) in moderate to high yields and high selectivity. Also, the HT/Pd hydroarylation reaction with aryl iodides was attempted on norbornene and α,β-unsaturated ketones affording, respectively, exo-aryl bicyclo[2.2.1]heptanes and β-aryl ketones in moderate to high yields. All the reactions described benefit from using a heterogeneous catalyst with evident advantages in terms of reaction purification and recyclability of the catalyst.
Unsymmetrical pincer CNN palladium complex of 7-ferrocenylmethyl-3-methyl-3,7-diazabicyclo[3.3.1]nonane
Bulygina, Ludmila A.,Kagramanov, Nikolay D.,Khrushcheva, Natalya S.,Lyssenko, Konstantin A.,Peregudov, Aleksander S.,Sokolov, Viacheslav I.
, p. 169 - 175 (2017/06/20)
The new unsymmetrical ferrocenyl containing bispidine derivative 7 was synthesized as a ligand precursor in five steps starting from N-Boc-4-oxopiperidine. The corresponding palladium CNN pincer complex 8 was prepared by direct cyclopalladation of the ligand 7 with Li2PdCl4 in MeOH. The molecular structure of the obtained palladacycle was determined by multinuclear NMR (1H, 13C, 15N) and confirmed by X-ray diffraction analysis. The pincer complex 8 demonstrated high catalytic activity in some cross-coupling reactions of aryl halides with phenylboronic acid, norbornene and ethyl acrylate.
Cyclopalladate complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane
Bulygina,Khrushcheva,Peregudov,Sokolov
, p. 2479 - 2484 (2017/05/09)
A new (C,N,N)-pincer cyclopalladate unsymmetrical complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane (3-benzyl-7-methylbispidine) was synthesized and characterized. Catalytic performance of this complex was examined in the Heck and Suzuki reactions and in the norbornene hydroarylation.
Synthesis and catalytic activity of a complex of 1,1'-bis-isoquinoline N,N'-dioxide with PdCl2
Bulygina,Khrushcheva,Sokolov,Khodak
, p. 429 - 431 (2015/10/29)
A novel complex of 1,1'-bis-isoquinoline N,N'-dioxide with PdCl2 was synthesized. This complex efficiently catalyzes the Suzuki cross-couplings and hydroarylation of norbornene.
Palladium nanocarbon catalysts (Pd/CNT) as potential enantioselective heterogeneous systems. the behavior in the hydrogenation and hydroarylation of unsaturated substrates
Abramova,Turova,Davidovich, Yu. A.,Sokolov
, p. 216 - 218 (2015/10/05)
Hydroxy-CNT were modified with optically active α-amino acids. The resulting chiral derivatives were directly palladated with Pd2dba3 and used to catalyze the hydrogenation of α-acetamidostyrene and α-phenylcinnamic acid as well as t
Synthesis, structure, and catalytic activity of complexes of 1,1′-bisisoquinoline with PdCl2 and NiCl2
Khrushcheva,Bulygina,Starikova,Sokolov
, p. 883 - 889 (2015/02/05)
New complexes of 1,1′-bisisoquinoline with PdCl2 and NiCl2 were synthesized. The structures of the complexes were established by X-ray diffraction. The PdII complex acts as a catalyst for the Suzuki and Heck reactions and the hydroarylation of norbornene. As exemplified by the Suzuki reaction, the NiII complex can also be used as a catalyst.
Norbornene hydroarylation catalyzed by ferrocene palladacycle complexes
Khrushcheva,Bulygina,Sokolov
, p. 1553 - 1555 (2013/11/19)
Two ferrocene derivatives containing palladacycles with bidentate (C,N) and tridentate (C,N,N) ligands were successfully used as catalysts for the hydroarylation of norbornene.
Heck-Matsuda reactions catalyzed by a hydroxyalkyl-functionalized NHC and palladium acetate
Penafiel, Itziar,Pastor, Isidro M.,Yus, Miguel
supporting information; scheme or table, p. 3151 - 3156 (2012/07/03)
The functionalized NHC obtained from salt 2 is a good ligand for palladium in the Heck-Matsuda reaction of arenediazonium salts and different alkenes. The reaction is performed with low catalyst loading (0.5-1 mol-% of Pd) and in the absence of a base for acrylates. The protocol is also useful for the preparation of cinnamide derivatives. Compound U-77863 has been prepared successfully in good isolated yield. Cyclohexene was found to be an appropriate substrate for the reaction, giving the corresponding 1-arylcyclohexene as a single regioisomer under the studied reaction conditions. The optimal parameters of the reaction were studied by employing a design of experiments approach. Thus, the use of a small set of reactions allows the trends of the different factors to be studied. This study revealed that the best catalytic system is formed by combination of Pd(OAc)2 and salt 2 in a 1:2 ratio. This catalytic system produces better results without the use of a base. Copyright
