1801-62-3

Usage

Uses

Used in Analytical Chemistry:
1,3-Dimethyl-2-thiohydantoin is used as a reactant or intermediate compound for its reactivity and compatibility with various functional groups, making it a valuable tool in analytical chemistry research.
Used in Pharmaceutical Research:
1,3-Dimethyl-2-thiohydantoin is used as a potential candidate for pharmaceutical applications, as researchers continue to study its properties and possible uses in the development of new drugs.

Upstream product

• 74404-63-0 1-cyanomethyl-1,3-dimethylthiourea 
• 556-61-6 methyl thioisocyanate 
• 5616-32-0 (methylamino)acetonitrile 
• 7647-01-0 hydrogenchloride 
• 107-97-1 sarcosine 
• 13515-93-0 N-methylglycine methyl ester hydrochloride 
• 861552-34-3 C₅H₁₀N₂O₂S 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 67-56-1 methanol 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 54118-10-4 5-(1,3-dimethyl-5-oxo-2-thioxo-imidazolidin-4-ylidene)-3-(3-ethyl-3H-benzothiazol-2-ylidenemethyl)-cyclohex-3-enecarboxylic acid amide 
• 2445-60-5 1,3-dimethyl-5-[2-(1-methyl-pyrrolidin-2-ylidene)-ethylidene]-2-thioxo-imidazolidin-4-one 
• 106164-71-0 5-[(1,3-dimethyl-pyrrolidin-2-yliden)-ethylidene]-1,3-dimethyl-2-thioxo-imidazolidin-4-one 
• 473739-41-2 1,3-dimethyl-5-[(E)-1-phenylmethylidene]-2-thioxoimidazolidin-4-one 
• 354119-53-2 5-((E)-3,4,5-trimethoxybenzylidene)-1,3-dimethyl-2-thiohydantoin 
• 354119-54-3 5-((E)-3,4-methylenedioxybenzylidene)-1,3-dimethyl-2-thiohydantoin 

Relevant academic research and scientific papers

Novel rhodanine derivatives induce growth inhibition followed by apoptosis

We have designed and synthesized three novel compounds, 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4- oxazolidinedione (ITO-1), and 5-benzilidene-3-ethyl rhodanine (BTR-1), and have tested their chemotherapeutic properties. Our results showed that all three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC50 value of BTR-1 was estimated to be a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

α-Thioureidoalkylation of urea heteroanalogs

α-Thioureidoalkylation of urea heteroanalogs such as thiosemicarbazide, amino-guanidine, sulfamide, and sulfonamides with 4,5-dihydroxyimidazolidine-2-thiones has been studied. Previously unknown 4,5-bis[thiosemicarbazido(guanidinoamino)]imidazolidine-2-thiones, 5,7-dialkylperhydroimidazo[4,5- e][1,2,4]triazine-3,6-dithiones, 4,6-diethyl-5(3H)-thioxotetrahydro-1 H-imidazo[4,5- c][1,2,5]thiadiazole 2,2-dioxide, and 1,3-dialkyl-4-[guanidinoimino(arylsulfonylimino)]imidazolidine- 2-thiones have been synthesized.

Oxidative desulfurization of azole-2-thiones with benzoyl peroxide: Syntheses of ionic liquids and other azolium salts

1-Alkyl-3-methylimidazole-2-thiones were prepared from amino esters in one pot and converted to inherently halide-free 1-alkyl-3-methylimidazolium benzoates by oxidation with benzoyl peroxide followed by a novel anion exchange. Also reported are the outcomes of exchanges with other anions, acidifications of the imidazolium benzoates to other salts, and extension of the method to the syntheses of 1,3-diphenylimidazolium and 3-methyl- and -butylthiazolium salts. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Synthesis of 3-substituted 5-arylidene-1-methyl-2-Thiohydantoins under microwave irradiation

A mono-modal microwave oven was used to expedite the synthesis of small libraries of 3-substituted 1-methyl-2-thiohydantoins and 3-substituted 5-arylidene-1-methyl-2-thiohydantoins. In comparison with the traditional reflux methods, similar or higher yields were obtained.