180869-38-9

Basic information

• Product Name: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL
• Synonyms: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL;4-(DiMethoxyMethyl)-N-MethylpyriMidin-2-aMine
• CAS NO: 180869-38-9
• Molecular Formula: C₈H₁₃N₃O₂
• Molecular Weight: 183.21
• Mol File: 180869-38-9.mol

Chemical Properties

• Boiling Point: 270.4°C at 760 mmHg
• Flash Point: 117.3°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 0.00684mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL(180869-38-9)
• EPA Substance Registry System: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL(180869-38-9)

Safety Data

• Hazardous Substances Data: 180869-38-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL is used as a reagent in the synthesis of heterocyclic compounds, which are essential components in the development of various pharmaceuticals. Its role as a key building block in the production of these compounds is crucial for creating new and effective medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL serves as an intermediate for the production of agrochemicals, contributing to the development of pesticides and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL is used as a reagent in organic synthesis, where it aids in the formation of complex organic molecules. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide range of chemical compounds.
Safety Precautions:
It is important to handle 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL with care, as it can be harmful if ingested, inhaled, or absorbed through the skin. Appropriate safety measures, including the use of personal protective equipment and proper disposal methods, should be taken when working with this chemical to ensure the safety of individuals and the environment.

InChI:InChI=1/C8H13N3O2/c1-9-8-10-5-4-6(11-8)7(12-2)13-3/h4-5,7H,1-3H3,(H,9,10,11)

Upstream product

• 67751-23-9 (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one 
• 22661-87-6 1-methylguanidine hydrochloride 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 165807-05-6 4-(dimethoxymethyl)pyrimidin-2-amine 
• 74-88-4 methyl iodide 
• 180869-36-7 4-dimethoxymethyl-2-methylsulfanylpyrimidine 
• 874279-26-2 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine 
• 74-89-5 methylamine 
• 67751-23-9 4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one 

Downstream Products

• 180869-39-0 2-(methylamino)pyrimidine-4-carbaldehyde 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS USED AS FGFR INHIBITORS

The present invention relates to a heterocyclic compound, a pharmaceutical composition containing the same, a preparation method thereof, and use thereof as a fibroblast growth factor receptor (FGFR) inhibitor. The compound is a heterocyclic compound as shown in Formula I, or a pharmaceutically acceptable salt, prodrug, solvent compound, polymorph, isomer or stable isotopic derivative thereof. The present invention further relates to use of the compound for the treatment or prevention of related diseases which are FGFR-mediated such as cancer, and a method for applying the compound to treat said diseases.

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS

This invention relates to 8-Heteroarylpurine Mnk2 Inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.

INDOLE OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING IκB KINASE

The invention relates to compounds of formula (I). Said compounds are suitable for producing medicaments for the prophylaxis and treatment of diseases, the progression of which involves increased activity of IκB kinase.

SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Pyrimidine analogs of the pyridinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-methoxypyrimidin-4-yl, or 2- methylaminopyrimidin-4-yl for pyridin-4-yl effectively dissociates CSBP/p38 kinase from P450 inhibition for this series and furthermore achieves an increase in oral activity.