181780-53-0

Upstream product

• 5532-86-5 benzyl cyanoformate 
• 82409-04-9 tert-butyl N-{3-[(3-aminopropyl)amino]propyl}carbamate 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 75178-96-0 N-Boc-1,3-diaminopropane 
• 39945-54-5 benzyl N-(3-bromopropyl)carbamate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 56-18-8 bis(3-aminopropyl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122248-80-0 benzyl N-[3-[(3-aminopropyl)amino]propyl]carbamate 
• 181780-44-9 N¹-tert-butoxycarbonyl-N³-(2-cyanoethyl)-1,3-propanediamine 
• 181780-34-7 C₁₉H₂₅Cl₃N₂O₆ 
• 160291-51-0 N-(tert-butoxycarbonyl)-N'-(benzyloxycarbonyl)-1,3-propanediamine 

Downstream Products

• 936025-72-8 [BOC][Cbz][NPN]2SuOH 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE

The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

MODIFIED MACROMOLECULE

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a res

Synthesis of Carbamate Protected Spermidine Homologues Through α,ω-Alkanediamines

The total synthesis of three triamines selectively protected in the primary amino groups (1a-c) and two triamines protected in the secondary amino function and in one of the primary amino functions (2a and 2c), based on a simple and efficient procedure, is described.