18190-25-5

Basic information

• Product Name: Butanamide, 4-hydroxy-N,N-dimethyl-
• Synonyms: 4-hyroxybutanamide;4-hydroxy-N,N-dimethylbutyramide;γ-hydroxybutyric acid dimethylamide;β-Hydroxy-N,N-dimethylbutyramid;4-hydroxy-N,N-dimethylbutanamide
• CAS NO: 18190-25-5
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Mol File: 18190-25-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanamide, 4-hydroxy-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 4-hydroxy-N,N-dimethyl-(18190-25-5)
• EPA Substance Registry System: Butanamide, 4-hydroxy-N,N-dimethyl-(18190-25-5)

Safety Data

• Hazardous Substances Data: 18190-25-5(Hazardous Substances Data)

Upstream product

• 37499-22-2 (CH₃)2SbO(CH₂)3CON(CH₃)2 
• 96-48-0 4-butanolide 
• 124-40-3 dimethyl amine 
• 74-89-5 methylamine 
• 75-21-8 oxirane 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 26717-47-5 clofibride 
• 37941-69-8 γ-hydroxybutyric acid monomethylamide 
• 13330-96-6 4-dimethylamino-1-butanol 
• 61002-01-5 2-[4-(4-Chloro-benzoyl)-phenoxy]-2-methyl-propionic acid 3-dimethylcarbamoyl-propyl ester 

Relevant articles and documents

RAPAMYCIN ANALOGS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Preparation of N-methyl-2-pyrrolidone (NMP)

N-Methyl-2-pyrrolidone (NMP) is prepared by preparing a mixture comprising monomethylamine, dimethylamine and trimethylamine and ammonia in a first process step by reacting ammonia with methanol at elevated temperature in the presence of a catalyst, separating 10 off the ammonia, reacting the mixture comprising the methylamines with gamma-butyrolactone (γ-BL), in a molar ratio of monomethylamine to γ-BL of at least 1 in a second process step at elevated temperature and superatmospheric pressure, separating NMP and unreacted methylamines from the reaction product and returning unreacted methylamines to the first process step for reaction with methanol and ammonia.

A Trialkylstannane-Mediated Approach to Acyloin Products

α-Alkoxy organolithium compounds, generated through the treatment of the corresponding tri-n-butylstannane with n-BuLi, smoothly condense with N,N-dimethylamides to afford α-alkoxy carbonyl products.This condensation is functionally equivalent to a regiocontrolled acyloin condensation.