37941-69-8

Basic information

• Product Name: 4-hydroxy-N-methylbutyramide
• Synonyms: 4-hydroxy-N-methylbutyramide;N-Methyl-4-hydroxybutanamide;ButanaMide, 4-hydroxy-N-Methyl-;4-hydroxy-N-MethylbutanaMide;4-HYDROXY-N-METHYLBUTANAMIDE(WXC07557)
• CAS NO: 37941-69-8
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• EINECS: 253-726-7
• Mol File: 37941-69-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 32-34 °C
• Boiling Point: 327.8°Cat760mmHg
• Flash Point: 152°C
• Appearance: /
• Density: 1.023g/cm³
• Vapor Pressure: 1.49E-05mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.82±0.10(Predicted)
• CAS DataBase Reference: 4-hydroxy-N-methylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-N-methylbutyramide(37941-69-8)
• EPA Substance Registry System: 4-hydroxy-N-methylbutyramide(37941-69-8)

Safety Data

• Hazardous Substances Data: 37941-69-8(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-N-methylbutanamide is an intermediate in the synthesis of potential hypotensive agents.

InChI:InChI=1/C5H11NO2/c1-6-5(8)3-2-4-7/h7H,2-4H2,1H3,(H,6,8)

Upstream product

• 96-48-0 4-butanolide 
• 74-89-5 methylamine 
• 1121-07-9 N-methylsuccinimide 
• 18190-25-5 N,N-dimethyl-γ-hydroxybutyramide 
• 124-40-3 dimethyl amine 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 

Downstream Products

• 340026-90-6 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diethylamino)[3-(N-methylaminocarbonyl)-1-propyloxy]phosphinyl-2'-deoxythymidine 
• 1121-07-9 N-methylsuccinimide 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 120-94-5 1-Methylpyrrolidine 
• 382600-67-1 5'-thymidyl benzyl N-methyl-N-(4-chlorobutyl) phosphoramidate 

Relevant articles and documents

RAPAMYCIN ANALOGS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

A Study on the Intramolecular Mitsunobu Reaction of N6-(ω-Hydroxyalkyl)adenines

The cyclization of N6-(ω-hydroxyalkyl)adenines with a N6H-group leads to N6,N1 ring closure regardless of the method of the cyclization that was used. Five-membered to eight-membered rings were obtained using NBS/PPh3; however, under Mitsunobu conditions, the eight-membered fused purine was not formed. Surprisingly, the cyclization of N6-methyl-N6-(4-hydroxybutyl)adenine only leads to N6,N7 ring closure using both methods.

A valsartanamide dinitrate derivative for the treatment of vascular and metabolic diseases

A dinitrate ester of a valsartanamide is described. It has superior properties in the treatment of vascular and metabolic diseases.