1821-27-8

Usage

Chemical Properties

Redish-Brown Crystalline Solid

InChI:InChI=1/C12H9N3O4/c16-14(17)11-5-1-9(2-6-11)13-10-3-7-12(8-4-10)15(18)19/h1-8,13H

Upstream product

• 56-23-5 tetrachloromethane 
• 13916-77-3 bis-(4-nitro-phenyl)-nitroso-amine 
• 64-17-5 ethanol 
• 836-30-6 4-ntrophenyl(phenyl)amine 
• 603-52-1 ethyl diphenylcarbamate 
• 3665-70-1 p-nitrodiphenylnitrosamine 
• 6322-39-0 N,N'-bis-(p-nitrophenyl)guanidine 
• 64-19-7 acetic acid 
• 154396-66-4 nitro-bis-(4-nitro-phenyl)-amine 
• 141-78-6 ethyl acetate 
• 100-01-6 4-nitro-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 586-78-7 para-nitrophenyl bromide 
• 382165-80-2 N-nitrosodiphenylamine 

Downstream Products

• 13916-77-3 bis-(4-nitro-phenyl)-nitroso-amine 
• 537-65-5 4,4'-diaminodiphenylamine 
• 970-76-3 2,4-dinitro-N-(4-nitrophenyl)aniline 
• 2908-76-1 bis(2,4-dinitrophenyl)amine 
• 102467-19-6 N,N-bis-(4-nitro-phenyl)-trans-cinnamamide 
• 16320-52-8 4,4'-dinitrodiphenyl(methyl)amine 
• 97510-15-1 4-[Bis-(4-nitro-phenyl)-amino]-benzonitrile 
• 31438-32-1 tetrakis-(4-nitro-phenyl)-hydrazine 
• 20440-93-1 tris(4-nitrophenyl)amine 
• 117847-23-1 4,4',2''-trinitrotriphenylamine 
• 1100-10-3 4,4'-dinitrotriphenylamine 
• 2420-88-4 4,4′-diaminodiphenylmethylamine 
• 374562-12-6 N,N-bis(4-maleimidophenyl)(methyl)amine 
• 1220986-82-2 C₁₄H₁₀ClN₃O₅ 

Relevant academic research and scientific papers

Synthesis of Amides by Nucleophilic Substitution of Hydrogen in 3-Nitropyridine

3-Nitropyridine reacted with nitrogen-centered carboxylic acid amide anions in anhydrous DMSO in the presence of K3Fe(CN)6 via oxidative nucleophilic substitution of hydrogen to give previously unknown N-(5-nitropyridin-2-yl) carboxa

A terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines

A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides with 1° anilines, especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.

High-Throughput Mass Spectrometry Screening Platform for Discovering New Chemical Reactions under Uncatalyzed, Solvent-Free Experimental Conditions

A gas-phase high-throughput reaction screening platform was developed for the first time to study chemical structures of closely related functional groups and for the discovery of novel organic reaction pathways. Experiments were performed using the contained atmospheric pressure chemical ionization (APCI) source that enabled nonthermal, nonequilibrium plasma chemistry to be monitored by mass spectrometry (MS) in real time. This contained-APCI MS platform allowed an array of reagents to be tested, resulting in the studies of multiple gas-phase reactions in parallel. By exposing headspace vapor of the selected reagents to corona discharge, solvent-free Borsche-Drecsel cyclization reaction, Katritzky chemistry, and Paal-Knorr pyrrole synthesis were examined in the gas phase, outside the high vacuum environment of the mass spectrometer. A new radical-mediated hydrazine coupling reaction was also discovered, which provided a selective pathway to synthesize secondary amines without using a catalyst. The mechanisms of these atmospheric pressure gas-phase reactions were explored through the direct capture of intermediates and via comparison with the corresponding bulk solution and droplet-phase reactions.

Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.

Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity

Many dyes for long-lasting hair coloring contain aromatic amines that undergo oxidative polymerizations, resulting in allergic contact dermatitis, with the potential to develop serious toxic effects. Among these amines, para-phenylenediamine (PPD) is a small molecule form of aniline commonly used in beauty products despite being a known allergen to humans. Hence, in this study we designed and synthesized safer PPD analogues through the synthesis of oligomeric PPD and the introduction of bulky side chains on PPD to overcome the PPD dye's toxicity. We hypothesized that (a) an increase in the molecular size of PPD by addition of the PPD monomer unit on free amines and (b) strategic functionalizations at the ortho position of PPD with strong electron-donating bulky groups are able to maintain the hair coloring properties, and increase the resistance to binding to skin proteins and therefore decrease the chance of skin sensitization. 13 oligomers were synthesized, with the aim to produce safer hair dyes while minimising eventual toxicity to humans. In particular, oligomers with bulky sidechains, PPD 6 (13), PPD 7 (14) and PPD 8 (15), displayed weak-to-moderate (27.1%, 24.1% and 34.0%) sensitization potential. The results confirmed the importance of having bulky and strong electron donating O-alkyl substituents in order to decrease the reactivity of PPD analogues towards skin proteins, thus preventing the interaction with immune cells and providing safer hair dyes.

DERIVATIVES OF PPD USEFUL FOR COLORING HAIR AND SKIN

The is provided a compound of formula I or II or physiologically acceptable salts or solvates, or oxidised derivatives thereof: where R1 to R3, R13 and R14 are as defined herein. Also disclosed herein are methods of dyeing hair or (temporarily) tattooing the skin using the compounds of formula I or II (or physiologically acceptable salts or solvates, or oxidised derivatives thereof) in a suitable composition.

Carbazole as Linker for Dinuclear Gadolinium-Based MRI Contrast Agents

Ligands able to complex two gadolinium ions have been synthesized and characterized in view of the ability of the complexes to increase the spin relaxation of water protons. All ligands are based on the heptadentate diethylenetriaminetetraacetic acid (DTTA) chelator and carbazole as a rigid linker. Depending on the derivatization on the nitrogen atom of the five-membered ring, the compounds form small aggregates in aqueous solution, self-assemble to form micelles or bind to human serum albumin. In all cases, this leads to a marked increase in 1H relaxivity at nuclear Larmor frequencies between 20 and 60 MHz. Water exchange on the gadolinium ions as measured by 17O NMR relaxation is fast enough not to limit relaxivity. 1H nuclear magnetic relaxation dispersion profiles were also measured and analyzed using Solomon–Bloembergen–Morgan theory including Lipari–Szabo treatment to include internal motion or anisotropic rotation.

THE PREPARATION METHOD FOR 4-NITROSOANILINE

The present invention refers to 4-manufacturing method relates to with child Neel phosphorus nitro, more particularly sodium urate (sodium urate), or their mixtures (potassium urate) potassium urate a urate in response to 40 to 120 °C nitrobenzene mono salt 4-nitro by the inclusion of step of manufacturing a nitrosoaniline, reactants use urate forming silicide film having excellent thermal stability the carbonate and ammonia and the like of a high yield conversion and without the formation of a leaving component 4-nitrosoaniline nitro method relates to manufacturing. (by machine translation)

A process for the preparation of methylene blue (by machine translation)

The present invention provides a method for preparing methylene blue, belongs to the fine the technical field of chemical synthesis. This invention, in order to the para-nitroaniline and nitrobenzene in the presence of a base to obtain the aromatic nucleo

Practical synthesis of aromatic dithiocarbamates

Oxidation-sensitive N,N-diaryl dithiocarbamates (DTCs) are synthesized in good yields by the generation of metal amide salts from N-benzoyl precursors, followed by addition of CS2. para-Substituted diphenylamines are prepared by electrophilic aromatic substitution of diphenylbenzamide and saponification. Deacylation of electron-rich species such as bis(p-dimethylaminophenyl)benzamide is challenging because of the oxidative sensitivity of the anionic intermediate but could be achieved in good yield by using n-BuLi to generate a hemiaminal adduct, prior to acidification. The N,N-diaryl DTCs are stable as alkali salts and can be used to produce densely packed monolayers on gold surfaces. Copyright