1912-31-8

Usage

Uses

Used in Scientific Research:
Propyl methanesulphonate is used as a mutagen for inducing mutations, particularly in genetic toxicology studies. Its mutagenic properties make it a valuable tool in research settings for understanding the mechanisms of genetic mutations and their effects on cellular processes.
Used in Drug Development:
Propyl methanesulphonate is used as a cytotoxic agent in the development of cancer therapeutics. Its cytotoxic effects can be harnessed to target and kill cancer cells, making it a potential candidate for the creation of novel anticancer drugs.
Used in Chemical Synthesis:
Propyl methanesulphonate is used as an intermediate in the synthesis of various organic compounds. Its reactivity and functional groups make it a useful building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Environmental Studies:
Propyl methanesulphonate is used as a tracer in environmental studies to track the movement and fate of pollutants in the environment. Its chemical properties allow it to be easily detected and monitored, providing valuable insights into the behavior of contaminants in ecosystems.
Used in Industrial Processes:
Propyl methanesulphonate is used as a catalyst or reactant in various industrial processes, such as the production of dyes, plastics, and other chemical products. Its versatility and reactivity make it a valuable component in the synthesis of a wide range of materials.

InChI:InChI=1/C4H10O3S/c1-3-4-7-8(2,5)6/h3-4H2,1-2H3

Upstream product

• 71-23-8 propan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 124-38-9 carbon dioxide 
• 7143-01-3 Methanesulfonic anhydride 
• 1825-63-4 trimethyl(propoxy)silane 
• 6581-64-2 2-propoxy-tetrahydro-pyran 

Downstream Products

• 6068-96-8 n-propyl hydroperoxide 
• 19398-89-1 trans-4-Decen 
• 862402-79-7 (S)-2-t-butoxycarbonylamino-3-(4-propoxyphenyl)propionic acid methyl ester 
• 105140-20-3 Methanesulfonatetetrahexyl-ammonium; 
• 106-94-5 propyl bromide 
• 113369-05-4 Methanesulfonatetetrapentyl-ammonium; 
• 113369-06-5 Methanesulfonatetetraheptyl-ammonium; 
• 98342-59-7 tetrabutylphosphonium methanesulfonate 
• 86471-19-4 Tributylhexadecylphosphonium-methansulfonat 
• 70098-05-4 tetraoctylammonium methanesulfonate 
• 80131-84-6 Boc-D-Tyr(n-Pr) 
• 75-75-2 methanesulfonic acid 
• 187737-37-7 propene 
• 54393-89-4 1-amino-2-nitro-4-n-propylthiobenzene 

Relevant academic research and scientific papers

Synthesis of N-alkylated pyrazolo[3,4-d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Fused pyrimidines, especially pyrazolo[3,4-d]pyrimidines, are among the most preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of biological activity. In this study, new derivatives of pyrazolo[3,4-d]pyrimidine were synthesized by alkylation of the N1 nitrogen atom. We synthesized 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2 from commercially available aminopyrazolopyrimidine 1 using N-iodosuccinimide as an iodinating agent. The synthesis of compound 2 started with nucleophilic substitution of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine with R–X (X: –OMs, –Br, –Cl), affording?N-alkylated pyrazolo[3,4-d]pyrimidine. We performed this synthesis using a weak inorganic base?and the mild temperature was also used for a two-step procedure to generate N-alkylated pyrazolo[3,4-d]pyrimidine derivatives. Also, all compounds were tested for their ability to inhibit acetylcholinesterase (AChE) and the human carbonic anhydrase (hCA) isoforms I and II, with Ki values in the range of 15.41 ± 1.39–63.03 ± 10.68 nM for AChE, 17.68 ± 1.92–66.27 ± 5.43 nM for hCA I, and 8.41 ± 2.03–28.60 ± 7.32 nM for hCA II. Notably, compound 10 was the most selective and potent CA I inhibitor with a significant selectivity ratio of 26.90.

1-Alkyl-3-methylimidazolium alkanesulfonate ionic liquids, [C nH2n+1mim][CkH 2k+1SO3]: Synthesis and physicochemical properties

A set of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids, [C nmim][CkSO3], formed by the variation of the alkyl chain lengths both in the cation and the anion (n = 1-6, 8, or 10; k = 1-4, or 6), was synthesised, with sixteen of them being novel. The ionic liquids were characterised by 1H and 13C NMR spectroscopy, and mass spectrometry. Their viscosities and densities as a function of temperature, as well as melting points and decomposition temperatures, were determined. The molecular volumes, both experimental and calculated, were found to depend linearly on the sum (n + k). the Owner Societies 2009.

HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS

A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.

An efficient one-pot conversion of THP and TMS ethers to sulfonate esters using FeCl3-montmorillonite K-10 clay

Various tetrahydropyranyl and trimethylsilyl ethers are efficiently transformed into the corresponding sulfonate esters with sulfonyl chlorides in the presence of FeCl3-Montmorillonite K-10 clay.

Synthesis of carbonates and related compounds from carbon dioxide via methanesulfonyl carbonates

Carbonate anions resulting from reaction of primary or secondary alcohols with carbon dioxide, when added to methanesulfonic anhydride in cooled acetonitrile solution, yield methanesulfonyl carbonates, a new class of synthetic intermediate. Base-mediated reaction of the methanesulfonyl carbonates with alcohols, thiols, and amines yields carbonates, thiocarbonates, and carbamates, respectively. Overall yields for the three steps vary from 19% to 42%.

Process for preparation of oxyglutaric acid ester derivatives

A process for preparing an oxyglutaric acid ester derivative of the formula: STR1 in which each of R1 and R2 is C1-5 alkoxy, C1-7 aralkyloxy, C7-9 halogenated aralkyloxy or phenyl, R4 is a hydroxyl-protecting group, and R5 is C1-10 alkyl which may have a substituent, comprises the steps of reacting a methyl phosphonate derivative or methyl phosphine oxide derivative with an oxyglutaric acid mono-ester to give a reaction product which comprises an oxyglutaric acid derivative having a phosphorus-containing group and a pentenedioic acid mono-ester (by-product), removing the pendenedioic acid mono-ester from the reaction product to isolate the oxyglutaric acid derivative, and converting the isolated oxyglutaric acid derivative into the oxyglutaric acid ester derivative. A process for obtaining an optically active oxyglutaric acid ester derivative is also disclosed.

Method of treating helminthiasis by parenteral or topical administration of sulfoxide derivatives of benzimidazoles

A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure STR1 wherein R1 is lower alkyl or phenyl-lower alkyl, and R2 is lower alkyl. Pharmaceutical compositions for use in the above method are also provided.

Benz (c) fluoran compounds and recording sheet containing them

Novel benz[c]fluoran compounds such as 2-phenylamino-8-diethylamino-benz[c]fluoran, 2-(2',4',6'-trimethylphenylamino)-8-diethylamino-benz[c]fluoran and N-[8-diethylaminobenz[c]fluoran-2-yl]-N-[6-diethylaminofluoran-2-yl]amine, which are useful as a coloring material for record material systems such as pressure-sensitive copying paper or heat-sensitive copying paper, wherein colored images formed by an electron-donoracceptor color-forming reaction between coloring material and acidic material.

Chromogenic compounds and method for preparation thereof

Chromogenic compounds for use in pressure sensitive recording sheets represented by the formula: SPC1 Are disclosed, wherein R1 and R2 are independently, hydrogen substituted or unsubstituted lower alkyl, aliphatic acyl, phenyl substituted aliphatic acyl, benzoyl, aralky, phenyl (the benzene nuclei of those substituents may be further substituted by chlorine, bromine, lower alkyl, lower alkoxy or nitro), allyl, allyl substituted by lower alkyl or phenyl, propargyl, or propargyl substituted by lower alkyl or a phenyl; R3 and R4 are independently lower alkyl, benzyl and phenyl (the benzene nuclei or those substiutents may be further substituted by chlorine, bromine, lower alkyl or lower alkoxy), either R1 or R2 being other than hydrogen when R3 and R4 are both ethyl groups.