312-63-0

Basic information

• Product Name: N-(4-Fluorophenyl)benzenesulfonaMide, 97%
• Synonyms: N-(4-Fluorophenyl)benzenesulfonaMide, 97%;4′-Fluorobenzenesulfonanilide;ELN484228;N-(p-Fluorophenyl)benzenesulfonamide;NSC 164389;α-Synuclein Blocker, ELN484228
• CAS NO: 312-63-0
• Molecular Formula: C₁₂H₁₀FNO₂S
• Molecular Weight: 251.2767032
• EINECS: 604-604-1
• Mol File: 312-63-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 379.1°Cat760mmHg
• Flash Point: 183°C
• Appearance: white to beige/
• Density: 1.374g/cm³
• Vapor Pressure: 6.02E-06mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble20mg/mL, clear
• CAS DataBase Reference: N-(4-Fluorophenyl)benzenesulfonaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Fluorophenyl)benzenesulfonaMide, 97%(312-63-0)
• EPA Substance Registry System: N-(4-Fluorophenyl)benzenesulfonaMide, 97%(312-63-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 312-63-0(Hazardous Substances Data)

Usage

Uses

ELN484228, is α-synuclein blocker. α-Synucleinis a key protein in Parkinson’s disease.

InChI:InChI=1/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H

Upstream product

• 2512-24-5 N-tert-butylbenzenesulfonamide 
• 54128-89-1 (FC₆H₄)N(HgC₆H₅)SO₂C₆H₅ 
• 98-10-2 benzenesulfonamide 
• 1765-93-1 4-fluoroboronic acid 
• 1829-81-8 N-(4-nitrophenyl)benzenesulfonamide 
• 350-46-9 4-Fluoronitrobenzene 
• 98-80-6 phenylboronic acid 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 98-09-9 benzenesulfonyl chloride 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 769-92-6 4-tert-Butylaniline 
• 873-55-2 sodium benzenesulfonate 
• 371-40-4 4-fluoroaniline 
• 5339-69-5 N-isopropylbenzenesulfonamide 

Downstream Products

• 1678-25-7 N-phenylbenzenesulfonamide 
• 54128-89-1 (FC₆H₄)N(HgC₆H₅)SO₂C₆H₅ 
• 19766-54-2 N-(4-(dimethylamino)phenyl)benzenesulfonamide 
• 134305-17-2 N-chloro-N-(4-fluorophenyl)benzenesulphonamide 
• 96622-94-5 4'-fluoro-2'-nitrobenzenesulfonanilide 
• 459-59-6 4-fluoro-N-methylaniline 
• 117199-41-4 (FC₆H₄)N(AuP(C₆H₅)3)SO₂C₆H₅ 
• 134305-22-9 N-(1-methyl-1H-pyrrol-2-yl)-N-(4-fluorophenyl)benzenesulphonamide 
• 96601-01-3 N-acetonyl-4'-fluoro-2'-nitrobenzenesulfonanilide 
• 117309-42-9 [Benzenesulfonyl-(4-fluoro-phenyl)-amino]-acetic acid 
• 75137-06-3 FC₆H₄HgN(SO₂C₆H₅)C₆H₄F 
• 75137-12-1 Cl₂C₆H₃HgN(SO₂C₆H₅)C₆H₄F 
• 75137-11-0 Cl₂C₆H₃HgN(SO₂C₆H₅)C₆H₄F 
• 75137-13-2 Cl₃C₆H₂HgN(SO₂C₆H₅)C₆H₄F 

Relevant articles and documents

Transition-Metal-Free and Visible-Light-Mediated Desulfonylation and Dehalogenation Reactions: Hantzsch Ester Anion as Electron and Hydrogen Atom Donor

Novel approaches for N- and O-desulfonylation under room temperature (rt) and transition-metal-free conditions have been developed. The first methodology involves the transformation of a variety of N-sulfonyl heterocycles and phenyl benzenesulfonates to the corresponding desulfonylated products in good to excellent yields using only KOtBu in dimethyl sulfoxide (DMSO) at rt. Alternately, a visible light method has been used for deprotection of N-methyl-N-arylsulfonamides with Hantzsch ester (HE) anion serving as the visible-light-absorbing reagent and electron and hydrogen atom donor to promote the desulfonylation reaction. The HE anion can be easily prepared in situ by reaction of the corresponding HE with KOtBu in DMSO at rt. Both protocols were further explored in terms of synthetic scope as well as mechanistic aspects to rationalize key features of desulfonylation processes. Furthermore, the HE anion induces reductive dehalogenation reaction of aryl halides under visible light irradiation.

Method for coupling nitroaromatic compound and boric acid compound to synthesize sulfonamide compound

The invention belongs to the field of organic synthesis, and specifically discloses a method for coupling a nitroaromatic compound and a boric acid compound to synthesize a sulfonamide compound. The method for coupling the nitroaromatic compound and the boric acid compound to synthesize the sulfonamide compound comprises the steps that in an organic solvent, pyrosulfite is used as a source of SO2,and heating is carried out for a coupling reaction, and then after the post-treatment, the sulfonamide compound is obtained. The method for coupling the nitroaromatic compound and the boric acid compound to synthesize the sulfonamide compound is simple in operation, does not require nitrogen protection, and can be carried out under air. The nitroaromatic compound and the boric acid compound are abundant in source, relatively low in price, high in reaction yield, wide in applicability of a substrate and free in metal residual. The method for coupling the nitroaromatic compound and the boric acid compound to synthesize the sulfonamide compound can be used for synthesizing a series of sulfonamide compounds, and the synthesized compounds have wide application value in the fields of pesticidesand medicines.

Method for ultrasound-assisted synthesis of N-arylsulfonamide

The invention discloses a method for ultrasound-assisted synthesis of N-arylsulfonamide. N-arylsulfonamide compound is synthesized by series reaction of nitro reduction/sulfonyl chloride reduction/sulfonamidation with taking aromatic nitro compounds, sulfonyl chloride and iron powder as raw materials under ultrasonic stirring conditions. Water is used as a reaction medium and a hydrogen source inthe reaction. The method has the advantages of cheap and easily obtained raw materials, simple and mild reaction conditions, environmental friendliness, saving energy, high reaction selectivity and high yield, excellent compatibility of substrate functional groups and high application value.