1843-16-9

Upstream product

• 3282-32-4 2-diazo-acetophenone 
• 103-85-5 monophenylthiourea 
• 38650-46-3 3,4-diphenyl-2-imino-4-thiazoline 
• 98-86-2 acetophenone 
• 536-74-3 phenylacetylene 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 
• 492-38-6 2-phenylacrylic acid 
• 70-11-1 α-bromoacetophenone 
• 4098-17-3 1-(1-azido-2-iodoethyl)benzene 
• 103-72-0 phenyl isothiocyanate 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 1074-52-8 ammonium phenyldithiocarbamate 
• 51034-34-5 potassium aniline dithiocarbamate 

Downstream Products

• 101727-95-1 phenyl-(4-phenyl-5-thiocyanato-thiazol-2-yl)-amine 
• 98626-89-2 N-phenyl-N-(4-phenyl-thiazol-2-yl)-acetamide 
• 101444-38-6 (3-acetyl-4-phenyl-3H-thiazol-2-ylidene)-phenyl-amine 
• 97118-81-5 N-(3-methyl-4-phenylthiazol-2(3H)-ylidene)phenylamine 
• 116153-37-8 4,4'-diphenyl-[5,5']bithiazolylidene-2,2'-dione-bis-phenylimine 
• 2211-45-2 (1H-benzoimidazol-2-ylmethyl)-phenyl-(4-phenyl-thiazol-2-yl)-amine 
• 72545-21-2 N,N-dimethyl-glycine phenyl-(4-phenyl-thiazol-2-yl)-amide 
• 72545-22-3 N,N-diethyl-glycine phenyl-(4-phenyl-thiazol-2-yl)-amide 
• 72545-25-6 N-pyridin-2-yl-glycine phenyl-(4-phenyl-thiazol-2-yl)-amide 
• 72545-26-7 N-pyrimidin-2-yl-glycine phenyl-(4-phenyl-thiazol-2-yl)-amide 
• 72545-20-1 N-phenyl-N-(4-phenyl-thiazol-2-yl)-2-piperidin-1-yl-acetamide 
• 72545-28-9 N-phenyl-N-(4-phenyl-thiazol-2-yl)-2-piperazin-1-yl-acetamide 
• 72545-19-8 2-morpholin-4-yl-N-phenyl-N-(4-phenyl-thiazol-2-yl)-acetamide 
• 72545-27-8 N,N-diphenyl-glycine phenyl-(4-phenyl-thiazol-2-yl)-amide 

Relevant academic research and scientific papers

Microwave promoted synthesis of functionalized 2-aminothiazoles

Microwave irradiation promotes the rapid one-pot synthesis of 2-aminothiazoles fromed via the condensation of α-bromoketones with thiourea.

Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Visible-Light-Mediated Additive-Free Decarboxylative Ketonization Reaction of Acrylic Acids: An Access to α-Thiocyanate Ketones

Visible-light-mediated additive-free decarboxylative functionalization of acrylic acids has been developed. The reaction uses inexpensive organic dye 9,10-dicyanoanthracene as a photocatalyst and uses the ubiquitous dioxygen as both an oxygen source and an oxidant. Through this mild and environmentally friendly method, a series of important α-thiocyanate ketones can be generated from easily available acrylic acids and ammonium thiocyanate. In addition, the facile transformation of product α-thiocyanate ketones makes this method have great potential for application in organic and pharmaceutical chemistry.

Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles from methyl aryl ketones and thiourea is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation. The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles from different ketones and thiourea.

Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands

A family of three spatially directional resorcin[4]arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- A nd environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, that is, RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or ethyl acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles.

One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.

NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME

This invention is directed to neuroprotective compositions and methods of using the same to treat neurodegenerative diseases.

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Aryliodoazide synthons: A different approach for diversified synthesis of 2-aminothiazole, 1,3-thiazole, and 1,3-selenazole scaffolds

Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

One-pot NBS-promoted synthesis of imidazoles and thiazoles from ethylarenes in water

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.