50553-98-5

Usage

Uses

Used in Pharmaceutical Development:
2,6-bis(4-methoxyphenyl)-4-phenylpyridine is used as a pharmaceutical intermediate for the development of new drugs due to its potential biological activities. It serves as a key component in the synthesis of medicinal compounds that target specific therapeutic areas.
Used in Organic Synthesis:
In the field of organic synthesis, 2,6-bis(4-methoxyphenyl)-4-phenylpyridine is used as a building block for the creation of complex organic molecules. Its unique structure allows for the formation of various functional materials with specific properties.
Used in Research:
2,6-bis(4-methoxyphenyl)-4-phenylpyridine is employed as a research compound to study its chemical properties, reactivity, and potential applications in different fields. Researchers use 2,6-bis(4-methoxyphenyl)-4-phenylpyridine to explore new synthetic routes and develop innovative methodologies in organic chemistry.
Used in the Preparation of Functional Materials:
2,6-bis(4-methoxyphenyl)-4-phenylpyridine is used as a precursor in the synthesis of functional materials with specific properties, such as光电材料 (photoelectric materials), 有机半导体 (organic semiconductors), and 有机光电子器件 (organic optoelectronic devices). Its incorporation into these materials can enhance their performance and expand their applications in various industries.

Upstream product

• 79-46-9 2-nitropropane 
• 96155-57-6 1-(4-methoxyphenyl)ethanone O-acetyl oxime 
• 108-88-3 toluene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 768-60-5 4-methoxyphenylacetylen 
• 5720-07-0 4-methoxyphenylboronic acid 
• 75-05-8 acetonitrile 
• 103-82-2 phenylacetic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-86-2 acetophenone 
• 959-23-9 4'-methoxychalcone 

Relevant academic research and scientific papers

Sulfonated poly(ether sulfone)s containing pyridine moiety for PEMFC

Sulfonated poly(ether sulfone)s with varied degree of sulfonation (DS) were prepared via post-sulfonation of synthesized pyridine based poly(ether sulfone) (PPES) using concentrated sulfuric acid as sulfonating agent. The DS was varied with different mole ratio of 4,4′-(2, 2-diphenylethenylidene)diphenol, DHTPE in the polymer unit. PPES copolymers were synthesized by direct polycondensation of pyridine unit with bis-(4-fluorophenyl)-sulfone, 4,4′-ulfonyldiphenol and DHTPE. The structure of the resulting PPES copolymer membranes with different sulfonated units were studied by 1H NMR spectroscopy and thermogravimetric analysis (TGA). Sorption experiments were conducted to observe the interaction of sulfonated polymer with water. The ion exchange capacity (IEC) and proton conductivity were evaluated according to the increase of DS. The water uptake (WU) of the resulting membranes was in the range of 17-58%, compared to that of Nafion 211, 28%. The membranes provided proton conductivities of 65-95 mS/cm in contrast to 103 mS/cm of Nafion 211.

A Facile and Green Synthesis of 2,4,6-Triarylpyridine Derivatives Using the Modified Mesoporous Organic Polymer Based on Calix [4]Resorcinarene: As an Efficient and Reusable Heterogeneous Acidic Catalyst

Abstract: The work describes an efficient one-pot synthesis of 2,4,6-trisubstituted pyridine derivatives through a three-component catalytic reaction. The procedure involves mesoporous organic polymer based on calix[4]resorcinarene in and functionalized b

Synthesis of Kr?hnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy

An efficient protocol for the synthesis of symmetrical and unsymmetrical 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines has been developed. The reaction proceeds smoothly utilizing iron(II) triflate as a catalyst and molecular oxygen as an oxidant with broad substrate scope. Mechanistic studies reveal that the reaction may be experiences an oxidative condensation followed by double alkynylation and amination process.

Pyridine Skeleton Synthesis Using Acetonitrile as C4N1 Units and Solvent

The first [3 + 2 + 1] methodology for pyridine skeleton synthesis via cascade carbopalladation/cyclization of acetonitrile, arylboronic acids, and aldehydes was developed. This reaction proceeds via six step tandem reaction sequences involving the carbopalladation reaction of acetonitrile, a nucleophilic addition, a condensation, an intramolecular Michael addition, cyclization, and aromatization. Delightfully, both palladium acetate and supported palladium nanoparticles catalyzed this reaction with similar catalytic performance. The characterization results of the fresh and used supported palladium nanoparticle catalysts indicated that the reaction might be performed via a Pd(0)/Pd(II) catalytic cycle that began with Pd(0). Furthermore, the products showed good fluorescence characteristics. The green homogeneous/heterogenous catalytic methodologies pave a new way for constructing the pyridine skeleton.

Copper-catalyzed efficient access to 2,4,6-triphenyl pyridinesviaoxidative decarboxylative coupling of aryl acetic acids with oxime acetates

An efficient and concise approach for the synthesis of 2,4,6-triphenyl pyridines has been developed through copper-catalysed oxidative decarboxylative coupling of C(sp3) aryl acetic acids with oxime acetates in DMF at 150 °C under an oxygen atm

A new route to triphenylpyridines utilizing ketoximes as building blocks via cascade reactions under iron-organic framework catalysis

Iron-based metal–organic framework VNU-20 was utilized as a heterogeneous catalyst for cascade reactions between ketoximes and dibenzyl ether to produce 2,4,6-triphenylpyridines. Additionally, benzyl alcohol and (dimethoxymethyl)benzene could be used as an alternative starting materials for the transformation. The oxidant exhibited a remarkable impact on the reactions, and di-tert-butylperoxide was the most appropriate candidate. The VNU-20 displayed higher efficiency than many homogeneous and heterogeneous catalysts. The catalyst was reusable for the cascade reactions without a noticeable deterioration in catalytic activity. This transformation is new, and would offer alternative routes to triphenylpyridines utilizing ketoximes as building blocks.

An efficient one pot three-component synthesis of 2,4,6-triarylpyridines using triflimide as a metal-free catalyst under solvent-free conditions

A simple and efficient protocol developed for one pot three-component synthesis of 2,4,6-triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate using the versatile super Br?nsted acid triflimide (HNTf2) as an effective catalyst is described. The reactions proceed well in the presence of 1 mol% of HNTf2 at 80 °c under solvent-free conditions and provide the corresponding triarylpyridines in good to excellent yields. The method reported has several advantages such as a metal-free and commercially available catalyst, mild reaction conditions and lower loading of catalyst.

Cationic organotin cluster [t-Bu2Sn(OH)(H2O)]2 2+2OTf?-catalyzed one-pot three-component syntheses of 5-substituted 1H-tetrazoles and 2,4,6-triarylpyridines in water

The cationic organotin cluster [t-Bu2Sn(OH)(H2O)]2 2+2OTf? is easy to prepare and stable in air. The catalytic activity of [t-Bu2Sn(OH)(H2O)]2 2+2OTf? as a neutral organotin Lewis acid catalyst is probed through the one-pot three-component syntheses of 5-substituted 1H-tetrazoles from aldehydes, hydroxylamine hydrochloride and sodium azide, and of 2,4,6-triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate. The reactions proceed well in the presence of 1?mol% of [t-Bu2Sn(OH)(H2O)]2 2+2OTf? in water and provide the corresponding 5-substituted 1H-tetrazoles and 2,4,6-triarylpyridines in good to excellent yields. The method reported has several advantages such as the catalyst being neutral, low catalyst loading and use of water as a green solvent.

B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines

The B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the construction of 2,4,6-triarylpyridines under metal-/solvent-free conditions has been successfully achieved. The advantages of this strategy include good functional group tolerance, low catalyst loading and high yields.

Preparation method of 2,4,6-triaryl substituted pyridine derivative

The invention discloses a preparation method of a 2,4,6-triaryl substituted pyridine derivative. The preparation method comprises the following steps: taking a aryl methyl ketone compound and a benzylamine derivative as raw materials, taking tri(pentafluorobenzene)borane as a catalyst, and reacting for 6-24 hours under the oxygen condition at 80-160 DEG C to obtain the 2,4,6-triaryl substituted pyridine derivative. According to the preparation method has the main beneficial effects that the reaction raw materials are easily available; the consumption of the catalyst can be as low as 0.5%; theexperiment operation is simple; the target compound can be prepared by a one-pot process; the substrate universality is high; the 2,4,6-triaryl substituted pyridine derivative with different substituent groups can be built; the further derivatization research can be facilitated.