187099-49-6

Basic information

• Product Name: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester
• Synonyms: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester
• CAS NO: 187099-49-6
• Molecular Weight: 289.45
• Mol File: 187099-49-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester(187099-49-6)
• EPA Substance Registry System: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester(187099-49-6)

Safety Data

• Hazardous Substances Data: 187099-49-6(Hazardous Substances Data)

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 615-36-1 2-bromoaniline 
• 615-43-0 2-iodophenylamine 
• 161117-84-6 tert-butyl 2-iodophenylcarbamate 
• 78839-75-5 2-bromo-N-(tert-butoxycarbonyl)aniline 

Downstream Products

• 199454-06-3 (2-ethynylphenyl)carbamic acid 1,1-dimethylethyl ester 
• 958301-44-5 2-(2-(methylthio)phenyl)quinoline 
• 89976-15-8 7-iodo-1H-indole 
• 70803-96-2 7-benzoylindole 
• 51417-51-7 7-bromo-1H-indole 
• 665034-20-8 tert-butyl 6-(3,4-methylenedioxyphenyl)-2-(trimethylsilylethynyl)phenylcarbamate 
• 665034-22-0 tert-butyl 6-(3,4-methylenedioxyphenyl)-2-ethynylphenylcarbamate 
• 52886-06-3 hippadine 
• 78860-34-1 2-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione 
• 78708-35-7 asterriquinone B1 
• 187099-51-0 tert-butyl (2-iodo-6-((trimethylsilyl)ethynyl)phenyl)carbamate 
• 187099-50-9 (2-Bromo-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester 
• 120-72-9 indole 
• 187099-53-2 (2-Benzoyl-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of indole-fused heteroacenes by cascade cyclisation involving rhodium(ii)-catalysed intramolecular C-H amination

Heteroacenes are potentially important materials for organic electronics and their syntheses are of topical interest. Herein we report the development of a catalytic, redox-neutral reaction for the synthesis of the 5,10-dihydroindolo[3,2-b]indole class of

Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)

The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)

Synthesis of 3,4-fused 2-quinolones from an (ortho-aminophenyl)propiolate via sequential cycloaddition/lactam formation

An N-phthalimide-protected (ortho-aminophenyl)propiolate was prepared by the carboxylation of the corresponding silylalkyne precursor with carbon dioxide. The obtained propiolate was further transformed to various 3,4-fused 2-quinolones via cycloadditions and subsequent deprotection/lactam formation.