18732-50-8Relevant academic research and scientific papers
An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes
Khairnar, Pankaj V.,Lung, Tsai-Hui,Lin, Yi-Jung,Wu, Chi-Yi,Koppolu, Srinivasa Rao,Edukondalu, Athukuri,Karanam, Praneeth,Lin, Wenwei
, p. 4219 - 4223 (2019/06/17)
α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramolecular Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.
Synthesis of some novel substituted phenylisoxazol phenoxy 2-methylpropanoic acids and there in vivo hypolipidemic activity
Mokale, Santosh N.,Dube, Pritam N.,Nevase, Manjusha C.,Sakle, Nikhil S.,Shelke, Vishakha R.,Bhavale, Swati A.,Begum, Afreen
, p. 422 - 428 (2016/02/19)
The novel series of phenylisoxazol phenoxy 2-methylpropanoic acid derivatives were synthesized and evaluated for their in vivo hypolipidemic activity by triton WR-1339-induced hyperlipidemia in rats. The newly synthesized compounds 5a and 5i showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index, TC:HDL risk ratios compared to cholesterol-induced hyperlipidemic control group. These molecules indeed have the potential to be developed as antihypolipidemic molecules.
Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives
Mokale, Santosh N.,Nevase, Manjusha C.,Sakle, Nikhil S.,Dube, Pritam N.,Shelke, Vishakha R.,Bhavale, Swati A.,Begum, Afreen
, p. 2155 - 2158 (2014/05/06)
The present study was undertaken to evaluate in-vivo hypolipidemic activity of a novel series of 2-methyl-2-(substituted phenyl isoxazol)phenoxyacetic acid derivatives by triton induced hyperlipidemia in rats. The newly synthesized compounds 5a, 5d and 5g showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index and increase in % protective activity compared to control group.
Synthesis of pyrazole and isoxazole in triethanolamine medium
Agrawal, Nitin N.,Soni
, p. 532 - 534 (2008/09/18)
Reactions of 2′-hydroxy chalcone dibromides 2a-1 with phenyl hydrazine and hydrazine hydrate afford pyrazoles 1a-1 and with hydroxylamine hydrochloride give isoxazoles 5a-f in triethanolamine medium. Similarly reaction of β-diketone 3b-e with phenyl hydra
Benzo-γ-pyrones. Part XVI. Synthesis and Characterisation of 3-(2-Hydroxyphenyl)-5-phenylisoxazole
Basinski, W.
, p. 579 - 582 (2007/10/02)
Synthesis of 3-(2-hydroxyphenyl)-5-phenylisoxazole (2) by oxidation of (E)-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one oxime (3) is described.Spectroscopic evidences (UV, IR, MS, 1H and 13C NMR) for the structure 2 are given.Key words: 3-(2-hydroxyphenyl)
Use of Nitrile Oxides in Synthesis. A Novel Synthesis of Chalcones, Flavanones, Flavones and Isoflavones
Thomsen, Ib,Torssell, Kurt B. G.
, p. 303 - 308 (2007/10/02)
Novel methodology is developed for a three-step synthesis of chalcones, flavanones, flavones and isoflavones. 1.Salicylaldoxime is chlorinated to the corresponding hydroxamoyl chloride in the presence of pyridine, and cycloadded to styrene and phenylacetylene. 2.The isoxazole derivatives formed are reductively cleaved over Raney-Ni to β-hydroxyketones or 1,3 diketones. 3.Acid-catalyzed cyclization gives the flavonoids.Use of ω-methoxy- or ω-dialkylamino-substituted styrenes (enamines) leads regioselectively to 4-aryl-substituted isoxazoles and derived isoflavones.
Synthesis of Some New 2--4H-1-benzopyran-4-ones
Fernandes, Peter S.,Gawri, Neelam V.
, p. 604 - 606 (2007/10/02)
The synthesis of a few new 4H-1-benzopyran-4-ones having substituents containing heterocyclic systems starting from -acetic acid and 2-hydroxy, 2,4-dihydroxy, 2,4,6-trihydroxy acetophenones has been described.
