187409-14-9Relevant articles and documents
Synthesis of Unsymmetrical 1,4-Dicarbonyl Compounds by Photocatalytic Oxidative Radical Additions
Dong, Ya,Li, Ruining,Zhou, Junliang,Sun, Zhankui
supporting information, p. 6387 - 6390 (2021/08/23)
Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This reaction utilizes a desulfurization process to generate electrophilic radicals, which add to α-halogenated alkenes and undergo further oxidation to deliver 1,4-dicarbonyl compounds. This mild and highly efficient method provides a valuable alternative to known strategies.
Catalytic Asymmetric Halogenation/Semipinacol Rearrangement of 3-Hydroxyl-3-vinyl Oxindoles: A Stereodivergent Kinetic Resolution Process
Cao, Weidi,Dai, Li,Feng, Xiaoming,Hu, Xinyue,Liu, Wen,Zeng, Zi,Zhou, Yuqiao
supporting information, p. 26599 - 26603 (2021/11/16)
A highly enantioselective halogenation/semipinacol rearrangement of isatin-derived allylic alcohols has been developed with a chiral N,N′-dioxide/ScIII complex as catalyst. This strategy involved a pivotal stereodivergent kinetic resolution process and provided a facile and efficient entry to optically active halo-substituted quinolone derivatives and quinoline alkaloids with a quaternary stereocenter simultaneously under mild reaction conditions. Based on the control experiments together with kinetic studies and DFT calculations, a possible catalytic cycle was proposed to illustrate the reaction process and enantiocontrol.
A practical synthesis of 3-chloro-α-bromostyrene starting from 3- chloroethylbenzene
Tanaka, Ken,Hosokawa, Akemi,Tanigawa, Yuichiro
, p. 211 - 218 (2007/10/03)
3-Chloro-α,β-dibromoethylbenzene was prepared via I2 catalyzed bromination of 3-chloro-α-bromoethylbenzene. It was dehydrobrominated with aqueous NaOH in the presence of n-Bu4N+HSO4- to give 3-chloro-
