18797-93-8

Upstream product

• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 5773-56-8 1,2-Diphenylethanol 
• 501-65-5 diphenyl acetylene 
• 952-06-7 deoxybenzoin oxime 
• 64-19-7 acetic acid 
• 13141-38-3 2-phenylethynylaniline 
• 35183-09-6 diphenylethanimine 
• 60-35-5 acetamide 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 57602-81-0 (S)-N-acetyl-1,3-diphenylpropylamine 

Relevant academic research and scientific papers

Efficient and practical synthesis of N-acetyl enamides from ketoximes by unique iron catalytic system

A new procedure for the iron-catalyzed synthesis of enamides from ketoximes was developed, and its mechanism was proposed. A unique reduction system, with the concerted use of KI and Na2S2O4, was involved. The reaction exhibited a wide substrate scope and gave good yields in a short reaction time. The procedure is operationally simple and also applicable for the large-scale synthesis.

METHOD FOR PREPARING ENAMIDE COMPOUND AND RUTHENIUM COMPLEX CATALYST USED THEREIN

Provided is a method for preparing an enamide compound, which includes reacting an organic azide compound having α-hydrogen and an anhydride by addition of a ruthenium complex catalyst in the presence of an ionic liquid, and a ruthenium complex catalyst u

BF3-Etherate-Promoted Cascade Reaction of 2-Alkynylanilines with Nitriles: One-Pot Assembly of 4-Amido-Cinnolines

A BF3-etherate-promoted cascade reaction of nitriles with 2-alkynylanilines is described. This method achieves the formation of two new C-N bonds through a reaction sequence of diazotization with t-BuONO, nucleophilic addition of the alkyne to

CATALYTIC PREPARATION OF ENAMIDES FROM ALKYL AZIDES AND ACYL DONORS

The present invention relates to a method to synthesize an enamide compound by generating imine which does not have a substituent group bonded to the nitrogen from an organic azide compound and conducting a reaction of the same with acyl doner. By using t

Synthesis of Enamides by Ruthenium-Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid

Enamides were synthesized by a ruthenium-catalyzed one-pot, one-step procedure from alkyl azides and acid anhydrides. The substrate scope includes not only secondary azides, but also primary aliphatic ones to give a wide range of enamides containing vario

Exploiting the Nucleophilicity of N-H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides

The nucleophilicity of N-unsubstituted imines, which were generated from alkyl azides by a ruthenium-catalyzed reaction, was investigated in the reaction with acid anhydrides. The initial products were N-acylimines, which isomerized to the corresponding e

Efficient synthesis of chiral β-arylisopropylamines by using catalytic asymmetric hydrogenation

(Chemical Equation Presented) Direct condensation of β-arylketones with acetamide afforded both Z and E enamides. The Z-configured substrates underwent hydrogenation with excellent enantioselectivity by using the Rh/tang-phos catalytic system (see scheme; tangphos = 1,1′-di-tert-butyl- [2,2′]-diphospholanyl). The product β-arylisopropylamines are important precursors to several drugs.

Application of hexakisacetonitrile iron (III) perchlorate in organic synthesis

Iron (III) perchlorate-CH3CN functions as an acid catalyst and promotes Ritter reaction. The reagent is not suitable to bring about oxidative decarboxylation and cleavage of glycols.