Tetrahedron Letters p. 1195 - 1196 (1997)
Update date:2022-07-30
Topics:
Mazzini, Claudio
Lebreton, Jacques
Alphand, Veronique
Furstoss, Roland
A seven-step enantioselective synthesis of (R)-(-)-baclofen 1 is described. The strategy developed involved as a key step, a microbiologically mediated Baeyer Villiger oxidation of the prochiral 3-(4'-chlorobenzyl)-cyclobutanone 3 which led to the optically pure (R)-(-)-4 lactone. This was further transformed throughout chemospecific reactions into the target molecule (R)-(-)-1.
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