Tetrahedron Letters p. 1195 - 1196 (1997)
Update date:2022-07-30
Topics:
Mazzini, Claudio
Lebreton, Jacques
Alphand, Veronique
Furstoss, Roland
A seven-step enantioselective synthesis of (R)-(-)-baclofen 1 is described. The strategy developed involved as a key step, a microbiologically mediated Baeyer Villiger oxidation of the prochiral 3-(4'-chlorobenzyl)-cyclobutanone 3 which led to the optically pure (R)-(-)-4 lactone. This was further transformed throughout chemospecific reactions into the target molecule (R)-(-)-1.
View MoreZUNYI CITY BEI YUAN CHEMICAL CO., LTD
website:http://www.china-beiyuan.com
Contact:+86-851-27751258
Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China
Jiaxing Carry Bio-Chem Technology Co.,Ltd
website:http://www.carrybiotech.com
Contact:0573-82788958
Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
Shanghai Harvest Chemical Ind. Co., Ltd.
Contact:021-51385350
Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
ABA Chemicals (Shanghai) Limited
Contact:021- 5115 9199-232
Address:Suite 18D, #201 Ningxia Road,
KAIYUAN CHEMICAL COMPANY LIMITED.
website:http://www.kaiyuanchem.com
Contact:+86-22-59891255/66/77
Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Doi:10.1016/j.dyepig.2017.02.049
(2017)Doi:10.1021/jo970616f
(1997)Doi:10.1016/j.tet.2008.11.081
(2009)Doi:10.1016/S0040-4039(97)00536-4
(1997)Doi:10.1016/S0022-328X(96)06835-0
(1997)Doi:10.1021/ol201093t
(2011)
