18951-46-7

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7400-08-0 p-Coumaric Acid 
• 106-47-8 4-chloro-aniline 
• 1073-67-2 4-vinylbenzyl chloride 
• 2628-17-3 4-Vinylphenol 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1145-93-3 diethyl 4-methoxybenzylphosphonate 
• 104-88-1 4-chlorobenzaldehyde 
• 5043-91-4 (E)-4-chloro-4'-methoxystilbene 
• 74-11-3 para-chlorobenzoic acid 
• 106-41-2 4-bromo-phenol 
• 540-38-5 p-Iodophenol 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 131530-01-3 C₁₉H₂₀BrClO 
• 118481-62-2 {4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-acetic acid ethyl ester 
• 1588534-24-0 C₂₈H₂₀Cl₂O₂ 
• 20357-42-0 N-(4-chlorobenzyl)-4-methoxyaniline 
• 73351-21-0 4-(((4-methoxyphenyl)amino)methyl)phenol 
• 127066-88-0 2-(5-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-pentylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 127066-87-9 2-(3-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid 
• 127066-95-9 2-(5-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-pentylsulfanyl)-6-methyl-3H-pyrimidin-4-one 
• 127066-94-8 2-(3-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propylsulfanyl)-6-methyl-3H-pyrimidin-4-one 
• 127066-84-6 2-(5-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-pentylsulfanyl)-3H-pyrimidin-4-one 
• 127066-83-5 2-(3-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propylsulfanyl)-3H-pyrimidin-4-one 
• 118481-65-5 2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propionic acid hydrazide 
• 118481-59-7 2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-propionic acid 
• 118481-64-4 {4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-acetic acid hydrazide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of halogenated e-stilbenols as promising antiaging agents

The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely descr

Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs

In this study, a series of resveratrol analogs was synthesized and the effects on the viability of pancreatic cancer cell lines were evaluated. The new molecules were designed by removing the 3- and 5-OH groups of resveratrol, and by incorporating other s

Iron-Catalyzed Nitrene Transfer Reaction of 4-Hydroxystilbenes with Aryl Azides: Synthesis of Imines via C=C Bond Cleavage

C=C bond breaking to access the C=N bond remains an underdeveloped area. A new protocol for C=C bond cleavage of alkenes under nonoxidative conditions to produce imines via an iron-catalyzed nitrene transfer reaction of 4-hydroxystilbenes with aryl azides is reported. The success of various sequential one-pot reactions reveals that the good compatibility of this method makes it very attractive for synthetic applications. On the basis of experimental observations, a plausible reaction mechanism is also proposed.

PPARα agonists based on stilbene and its bioisosteres: Biological evaluation and docking studies

A new series of gemfibrozil analogues conjugated with trans-stilbene were synthesized and evaluated with the aim of developing new PPARα agonists. The phenyls of stilbene were modified by introducing substituents in the ortho or para position and only the

Aerobic oxidative coupling of resveratrol and its analogues by visible light using mesoporous graphitic carbon nitride (mpg-C3N4) as a bioinspired catalyst

The first aerobic oxidative coupling of resveratrol and its analogues by mesoporous graphitic carbon nitride as a bioinspired catalyst with visible light has been developed. With this method, δ-viniferin and its analogues were synthesized in moderate to high yield. The metal-free conditions, visible-light irradiation, and the ideal oxidant, molecular oxygen, make this coupling reaction environmental friendly and practical. Copyright

Scope and limitations of the Heck-Matsuda-coupling of phenol diazonium salts and styrenes: A protecting-group economic synthesis of phenolic stilbenes

4-Phenol diazonium salts undergo Pd-catalyzed Heck reactions with various styrenes to 4′-hydroxy stilbenes. In almost all cases higher yields and fewer side products were observed, compared to the analogous 4-methoxy benzene diazonium salts. In contrast, the reaction fails completely with 2- and 3-phenol diazonium salts. For these substitution patterns the methoxy-substituted derivatives are superior. The Royal Society of Chemistry 2013.

Tandem heck/decarboxylation/heck strategy: Protecting-group-free synthesis of symmetric and unsymmetric hydroxylated stilbenoids

Ride the (micro)wave: The title strategy has been developed for the synthesis of various symmetric or unsymmetric hydroxylated stilbenoids utilizing 4-halophenols and acrylic acid as coupling partners (see scheme; DMA=N,N-dimethylacetamide, MW=microwave). Protecting groups are not necessary and a single palladium catalyst is used. Copyright

Catalytic application of dinuclear palladium(II) bis(thiosemicarbazone) complex in the Mizoroki-Heck reaction

A convenient synthesis of new square planar dinuclear palladium(II) terephthaldehyde bis(thiosemicarbazone) complex has been described. The compositions of the complex have been established by elemental analysis, spectral methods and single crystal X-ray crystallographic technique. The new complex acts as an active recyclable homogeneous catalyst for the Mizoroki-Heck reaction of electron deficient (activating) and electron rich (deactivating) aryl halides with various olefins under optimized conditions.

A short and efficient synthetic approach to hydroxy (E)-stilbenoids via solid-phase cross metathesis

Solid-phase cross metathesis of supported styrenyl ether with styrene derivatives afforded stilbenoids in high yields with complete (E)-selectivity, and this approach could be readily applied for a facile synthesis of a biologically important natural product, resveratrol.