192315-55-2Relevant academic research and scientific papers
Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13
Nolasco, Luca,Gonzalez, Manuel Perez,Caggiano, Lorenzo,Jackson, Richard F. W.
experimental part, p. 8280 - 8289 (2010/02/17)
(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected
Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13
Perez-Gonzalez,Jackson
, p. 2423 - 2424 (2007/10/03)
The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C
Total synthesis of the cyclic biphenyl ether peptides K-13 and OF494-III via S(N)Ar macrocyclizations of peptidyl ruthenium π-arene complexes
Janetka, James W.,Rich, Daniel H.
, p. 6488 - 6495 (2007/10/03)
Intramolecular nucleophilic aromatic substitution (S(N)Ar) of preformed ruthenium cyclopentadienyl cationic peptidyl π-complexes forms cyclic biphenyl ethers in convenient, high-yielding reactions. The utility of the method was demonstrated by the efficie
