327621-02-3Relevant articles and documents
Copper-Promoted O-Arylation of the Phenol Side Chain of Tyrosine Using Triarylbismuthines
Gagnon, Alexandre,Hébert, Martin,Le Roch, Adrien
supporting information, p. 5363 - 5367 (2020/08/27)
A general method for the O-arylation of the side chain of tyrosine using triarylbismuth reagents is reported. The reaction is mediated by copper diacetate, operates at 50 °C under oxygen in dichloromethane in the presence of pyridine, shows excellent functional group compatibility, and retains the integrity of the stereogenic center. The protocol was used to arylate the tyrosine residue of dipeptides and tripeptides.
Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13
Nolasco, Luca,Gonzalez, Manuel Perez,Caggiano, Lorenzo,Jackson, Richard F. W.
experimental part, p. 8280 - 8289 (2010/02/17)
(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected
Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13
Perez-Gonzalez,Jackson
, p. 2423 - 2424 (2007/10/03)
The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C