Free CoA as activator of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot
-
Add time:08/11/2019 Source:sciencedirect.com
The activity of 6-Hydroxymellein (cas 19314-92-2) (6HM) synthase, a multifunctional polyketide biosynthetic enzyme in carrot, was appreciably inhibited in the presence of ATP: citrate lyase, a CoA-scavenging enzyme. Catalytic rate of the synthase markedly decreased when deuterium-labeled NADPH was employed in the enzyme reaction, however, the isotope effect was appreciably reduced by the addition of free CoA. These observations suggest that CoA is the activator of 6HM synthase both in low and high concentrations, and the compound functions as the acyl acceptor for proper entry of the substrates and enhances the ketoreducing reaction, the rate limiting step of 6HM biosynthesis.
We also recommend Trading Suppliers and Manufacturers of 6-Hydroxymellein (cas 19314-92-2). Pls Click Website Link as below: cas 19314-92-2 suppliers
Prev:Activation of acyl condensation reaction of monomeric 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme, by free coenzyme A
Next:Epidemiological characteristics of human cytomegalovirus infection and glycoprotein H genotype in Chinese children) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Activation of acyl condensation reaction of monomeric 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme, by free coenzyme A08/10/2019
- Role of reducing co-factors in catalytic reactions of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot cells08/09/2019
- Transacylase-like structure and its role in substrate channeling of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot cell extracts08/08/2019
- Unusual arrangement of catalytic domains in head-to-tail associated homodimer of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme08/07/2019
- 6-Hydroxymellein (cas 19314-92-2) synthetase as a multifunctional enzyme complex in elicitor-treated carrot root extract08/06/2019
- Toxicity of 6-methoxymellein and 6-Hydroxymellein (cas 19314-92-2) to the producing carrot cells08/05/2019
- Dimer as the active form of a polyketide biosynthetic enzyme 6-Hydroxymellein (cas 19314-92-2) synthase08/04/2019
- Interaction between cerulenin and 6-Hydroxymellein (cas 19314-92-2) synthase in carrot cell extracts08/03/2019
- Induction of 6-methoxymellein 6-Hydroxymellein (cas 19314-92-2) production in carrot cells08/02/2019