19336-70-0

Basic information

• Product Name: 2-[(4-methylphenyl)carbamoyl]benzoic acid
• Synonyms: benzoic acid, 2-[[(4-methylphenyl)amino]carbonyl]-
• CAS NO: 19336-70-0
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.2686
• Mol File: 19336-70-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 372.4°C at 760 mmHg
• Flash Point: 179°C
• Density: 1.295g/cm³
• Vapor Pressure: 3.31E-06mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 2-[(4-methylphenyl)carbamoyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-methylphenyl)carbamoyl]benzoic acid(19336-70-0)
• EPA Substance Registry System: 2-[(4-methylphenyl)carbamoyl]benzoic acid(19336-70-0)

Safety Data

• Hazardous Substances Data: 19336-70-0(Hazardous Substances Data)

Usage

General Description

2-[(4-methylphenyl)carbamoyl]benzoic acid is a chemical compound composed of a benzoic acid molecule with a carbamoyl group attached to its 2-position, as well as a methylphenyl group attached to the carbamoyl group. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds, due to its potential therapeutic properties. 2-[(4-methylphenyl)carbamoyl]benzoic acid has the potential to act as an anti-inflammatory, analgesic, and antipyretic agent.5 It also shows potential as a lead compound for the treatment of various diseases such as cancer and diabetic nephropathy. Additionally, it has been studied for its potential use in the treatment of Alzheimer's disease, as it exhibits inhibitory activity against acetylcholinesterase, an enzyme associated with the progression of the disease.

Upstream product

• 85-44-9 phthalic anhydride 
• 106-49-0 p-toluidine 
• 67-64-1 acetone 
• 2142-03-2 2-p-tolylisoindoline-1,3-dione 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 7664-41-7 ammonia 
• 6139-63-5 2-(phenoxycarbonyl) benzoic acid 

Downstream Products

• 85-44-9 phthalic anhydride 
• 4300-33-8 N-(4-methylphenyl)-N'-phenylurea 
• 6296-09-9 (Z)-3-(p-tolylimino)isobenzofuran-1(3H)-one 
• 108475-12-3 2,3-Dihydro-3-hydroxy-2-p-tolyl-1H-isoindol-1-one 
• 520-03-6 N-phenylphthalimide 
• 89198-26-5 {Co(MPA)2(H₂O)2} 
• 105536-73-0 Cr(C₆H₄COOCONHC₆H₄CH₃)3 
• 2142-03-2 2-p-tolylisoindoline-1,3-dione 
• 129934-43-6 N-p-Tolylphthalisoimidium perchlorate 
• 106-49-0 p-toluidine 
• 96402-73-2 N-benzyl-N'-p-tolyl-phthalamide 
• 16497-44-2 N-phenyl-N'-p-tolyl-phthalamide 
• 97498-62-9 Methyl-N-p-tolyl-phthalamat 

Relevant articles and documents

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Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: Application to the synthesis of vernakalant

Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

An expeditious synthesis of imides from phthalic, maleic and succinic anhydrides and chemoselective C=C reduction of maleic amide esters

Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence of EDC. HCl and HOBt give cyclic imide derivatives. Reaction of monoacid monoamides independently, with SOCl 2 at 0-5°C give the monoamide monoester derivatives. Treatment of monoamide monoester of malic anhydride with NaBH4 leads to the unusual reduction of C=C grouping as well as the carbonyl group of the ester group to from monoamide monoalcohol of succinic anhydride. Preparation of monoamide monoalcohol of succinic anhydride can also be achieved by chemoselective reduction of monoamide monoester of malic anhydride with Mg turnings yielding monoamide monoester of succinic anhydride followed by reduction of the latter with NaBH4.