510-65-6

Basic information

• Product Name: 19-Hydroxy substance s
• CAS NO: 510-65-6
• Molecular Formula: C₂₁H₃₀O₅
• Molecular Weight: 362.463
• Mol File: 510-65-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 576.3°Cat760mmHg
• Flash Point: 316.3°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 1.12E-15mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 19-Hydroxy substance s(CAS DataBase Reference)
• NIST Chemistry Reference: 19-Hydroxy substance s(510-65-6)
• EPA Substance Registry System: 19-Hydroxy substance s(510-65-6)

Safety Data

• Hazardous Substances Data: 510-65-6(Hazardous Substances Data)

Usage

General Description

19-Hydroxy substances are a class of chemicals that contain a hydroxyl group (OH) attached to the 19th carbon atom in their molecular structure. These substances can be found in various natural sources, including plants and animals, and can also be synthesized in the laboratory. They have been found to exhibit a wide range of biological activities, including anti-inflammatory, antioxidant, and anticancer effects. Some 19-hydroxy substances, such as 19-hydroxyandrostenedione, have been studied for their potential use in hormone replacement therapy and treatment of hormone-related conditions. Overall, 19-hydroxy substances show promise as therapeutic agents for a variety of health conditions and continue to be the subject of ongoing research.

InChI:InChI=1/C21H30O5/c1-19-7-5-17-15(16(19)6-9-21(19,26)18(25)11-22)3-2-13-10-14(24)4-8-20(13,17)12-23/h10,15-17,22-23,26H,2-9,11-12H2,1H3/t15-,16-,17-,19-,20+,21-/m0/s1

Upstream product

• 640-87-9 cortexolone 21-acetate 
• 19357-45-0 17α,21-dihydroxy-4-pregnene-3,20-dione 17-acetate 
• 152-58-9 Cortexolone 

Downstream Products

• 2394-23-2 19,21-dihydroxypregn-4-ene-3,20-dione 
• 510-64-5 19-hydroxy-4-androstene-3,17-dione 

Relevant articles and documents

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale. The obtained C19-OH-cortexolone can be readily transformed to various synthetically useful intermediates including the industrially valuable 19-OH-androstenedione, which can serve as a basis for synthesis of C19-functionalized steroids as well as 19-nor steroidal drugs. Using this biocatalytic C19-hydroxylation method, the unified synthesis of six C19-hydroxylated pregnanes is achieved in just 4 to 9 steps. In addition, the structure of sclerosteroid B is revised on the basis of our synthesis.