193979-43-0

Basic information

• Product Name: ethyl 2-(6-chloro-2-phenyliMidazo[1,2-a]pyridin-3-yl)acetate
• Synonyms: ethyl 2-(6-chloro-2-phenyliMidazo[1,2-a]pyridin-3-yl)acetate
• CAS NO: 193979-43-0
• Molecular Formula: C₁₇H₁₅ClN₂O₂
• Molecular Weight: 314.7662
• Mol File: 193979-43-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(6-chloro-2-phenyliMidazo[1,2-a]pyridin-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(6-chloro-2-phenyliMidazo[1,2-a]pyridin-3-yl)acetate(193979-43-0)
• EPA Substance Registry System: ethyl 2-(6-chloro-2-phenyliMidazo[1,2-a]pyridin-3-yl)acetate(193979-43-0)

Safety Data

• Hazardous Substances Data: 193979-43-0(Hazardous Substances Data)

Upstream product

• 3278-34-0 ethyl 2-(ethoxythiocarbonylthio)acetate 
• 168837-18-1 6-chloro-2-phenylimidazo[1,2-a]pyridine 
• 1072-98-6 5-chloro-2-pyridylamine 
• 100-52-7 benzaldehyde 
• 196959-66-7 C₁₂H₉ClN₂ 
• 623-47-2 propynoic acid ethyl ester 
• 15121-89-8 ethyl 3-benzoyl acrylate 
• 98-86-2 acetophenone 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 39225-30-4 ethyl 3-benzoyl-3-bromopropionate 
• 71-36-3 butan-1-ol 

Downstream Products

• 365213-62-3 (6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid 

Relevant articles and documents

Visible light/Ir(III) photocatalytic initiation of xanthate-based radical-chain reactions: Xanthate group transfer and oxidative addition to aromatic systems

A photocatalyzed redox generation of radicals from O-ethyl xanthates to generate electrophilic radicals under photoredox catalysis, using Ir(ppy)3 and blue LEDs irradiation is described. The protocol can be used in classical xanthate-based inter- and intra-molecular group transfer reactions and oxidative radical addition to several heteroaromatic systems. The process does not require high temperature and reactions are cleaner compared with the traditional peroxide initiation. In the oxidative addition to aromatic systems, the oxidation process is part of the catalytic cycle and does not require a stoichiometric oxidant such as DLP which is particularly difficult to separate from the product.

Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

A metal-free process for the C-3 alkylation of imidazopyridines has been developed. Various alkylation products including alkyl ester-, cyano-, ketone- and amide-substituted imidazopyridines were prepared in good yields. With this method, a highly efficie

Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography

The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and aid information exchange have therefore clear value. Over the last few years, both synthetic chemistry and biological screening have benefited from automation, and a seamless chemistry-biology interface is now possible. We report here on the use of flow processes to perform synthesis and biological evaluation in an integrated manner. As proof of concept, a flow synthesis of a series of imidazo[1,2-a]pyridines, including zolpidem and alpidem, was developed and connected to a Frontal Affinity Chromatography screening assay to investigate their interaction with Human Serum Albumin (HSA). The Royal Society of Chemistry 2013.