37934-89-7

Usage

Uses

Used in Sunscreen Industry:
2,6-DIMETHYL-4-METHOXYBENZOIC ACID is used as a sunscreen agent for its ability to absorb UVB radiation, providing protection against harmful sun exposure and reducing the risk of skin damage and premature aging.
Used in Pharmaceutical Industry:
2,6-DIMETHYL-4-METHOXYBENZOIC ACID is used as an active pharmaceutical ingredient for its anti-inflammatory and analgesic properties, making it a valuable component in topical pain relief products and other medicinal formulations.
Used in Fragrance Industry:
2,6-DIMETHYL-4-METHOXYBENZOIC ACID is used as a fragrance ingredient for its unique scent profile, contributing to the creation of various perfumes, colognes, and other scented products.
Used in Food Industry:
2,6-DIMETHYL-4-METHOXYBENZOIC ACID is used as a flavoring agent to enhance the taste and aroma of various food products, providing a slightly bitter note that can complement and balance other flavors.
Used in Chemical Industry:
2,6-DIMETHYL-4-METHOXYBENZOIC ACID is used in the synthesis of various organic compounds, serving as a key intermediate in the production of other chemicals and materials.

InChI:InChI=1/C10H12O3/c1-6-4-8(13-3)5-7(2)9(6)10(11)12/h4-5H,1-3H3,(H,11,12)

Upstream product

• 31247-59-3 2,6-dimethyl-4-methoxybenzoyl chloride 
• 34743-49-2 4-methoxy-2,6-dimethylaniline 
• 21971-21-1 2-chloro-4-methoxybenzoic acid 
• 75-24-1 trimethylaluminum 
• 124-38-9 carbon dioxide 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 28636-93-3 2,6-dimethyl-4-hydroxybenzyl alcohol 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 19447-00-8 4-methoxy-2,6-dimethylbenzylaldehyde 
• 67-64-1 acetone 
• 87513-49-3 2,4-dinitrophenyl 4-methoxy-2,6-dimethylbenzoate 
• 61000-21-3 (4-methoxy-2,6-dimethylphenyl)methanol 

Downstream Products

• 87513-49-3 2,4-dinitrophenyl 4-methoxy-2,6-dimethylbenzoate 
• 1239952-30-7 [2-(4-methoxy-2,6-dimethylbenzoyl)-2,3-dihydro-1H-isoindol-5-yl]-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)methanone 
• 153968-41-3 (4-Methoxy-2,6-dimethyl-benzoyl)-phosphonic acid diethyl ester 
• 34743-49-2 4-methoxy-2,6-dimethylaniline 
• 114820-17-6 4-methoxy-2,6-dimethyl-benzoic acid amide 
• 75056-97-2 2,6-dimethyl-4-hydroxybenzoic acid 
• 31247-59-3 2,6-dimethyl-4-methoxybenzoyl chloride 
• 99730-38-8 4,4'-Dimethoxy-2,6,2',6'-tetramethyl-benzil 

Relevant academic research and scientific papers

Iron-Catalyzed Ortho C-H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand

Iron-catalyzed C-H functionalization of aromatics has attracted widespread attention from chemists in recent years, while the requirement of an elaborate directing group on the substrate has so far hampered the use of simple aromatic carbonyl compounds such as benzoic acid and ketones, much reducing its synthetic utility. We describe here a combination of a mildly reactive methylaluminum reagent and a new tridentate phosphine ligand for metal catalysis, 4-(bis(2-(diphenylphosphanyl)phenyl)phosphanyl)-N,N-dimethylaniline (Me2N-TP), that allows us to convert an ortho C-H bond to a C-CH3 bond in aromatics and heteroaromatics bearing simple carbonyl groups under mild oxidative conditions. The reaction is powerful enough to methylate all four ortho C-H bonds in benzophenone. The reaction tolerates a variety of functional groups, such as boronic ester, halide, sulfide, heterocycles, and enolizable ketones.

Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Steric and Electronic Control of the Dissociative Hydrolysis of 4-Hydoxybenzoate Esters

The introduction of two ortho methyl substituents changes the propensity of 4-hydroxybenzoates to react via the oxo-ketene pathway by nearly one million-fold; the increased reactivity of the hindered conjugate base over that of the parent is assigned to enhanced internal nucleophilicity of the 4-oxyanion.

Syntheses of 4-Hydroxy-2,6-dimethylbenzoic Acid and Its Higher Homologues

Syntheses of 4-hydroxy-2,6-dimethylbenzoic acid (2a) and its higher homologues, viz 4-hydroxy-2,6-dimethylphenylacetic acid (2b), 3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid (2c) and 4-(4-hydroxy-2,6-dimethylphenyl)butanoic acid (2d) are described.

Vinyl Cation Intermediates in Solvolytic and Electrophilic Reactions. 1. Solvolysis of α-Arylvinyl Derivatives

The solvolysis of 16 α-arylvinyl tosylates, bromides, and chlorides has been investigated in various alcohol-water mixtures and in acetic acid at several temperatures.All substrates were substituted with either 2-methyl or 2,6-dimethyl groups to accelerate the rates of reaction.The major or exclusive product isolated in most cases was the acetophenone arising from hydrolysis of the expected enol ethers or acetates during workup.The kinetics were simple first order in the vast majority of cases, with excess base added to prevent side reactions.Leaving group effects, Winstein-Grunwald m values, Schleyer Q values, and effects of solvent nucleophilicity all point to a limiting SN1 ionization generating a vinyl cation intermediate, in which there is little rear-side nucleophilic assistance by solvent.Substituent effects led to ρ values in the range -3.9 to -5.3 vs. ?+.Activation parameters are typical for an SN1 process, and ΔS% is insensitive to the presence of zero, one, or two o-methyl groups, as are the effects of solvent polarity on the rates.The results should therefore be directly comparable with other solvolytic or electrophilic reactions generating formally similar vinyl cation intermediates.