19448-36-3Relevant articles and documents
Total synthesis of the carbon analog of Δ6-PGI1
Shibasaki,Iseki,Ikegami
, p. 169 - 172 (1980)
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Synthesis of dl-9(O)-methano-Δ6-prostaglandin I1
Iseki,Mase,Okazaki,et al.
, p. 4448 - 4455 (1983)
Biologically interesting 9(O)-methano-Δ6-prostaglandin I1 (9(O)-methano-Δ6-PGI1), a chemically stable analog of prostacyclin (PGI2), was efficiently synthesized from 1,3-cyclooctadiene with high stereo- and regiochemical control. In all three biological test systems examined, 9(O)-methano-Δ6-PGI1 was found to be considerably less active than prostaglandin E1 (PGE1).
Efficient Synthesis of ω-[18F]Fluoroaliphatic Carboxylic Esters and Acids for Positron Emission Tomography
Belousov, Mikhail V.,Larkina, Mariia S.,Ozerskaya, Anastasia V.,Podrezova, Ekaterina V.,Tolmachev, Vladimir,Yusubov, Mekhman S.,Zhdankin, Viktor V.
, p. 6375 - 6381 (2020/10/20)
[18F]Fluoroaliphatic carboxylic acids are important PET tracers that have demonstrated a considerable potential to address the fatty acid oxidation-dependent processes in clinical patients. Herein, we report an efficient radiosynthetic approach to ω-[18F]fluoroaliphatic carboxylic esters and acids by nucleophilic radiofluorination of the readily available iodocarboxylic esters. Methyl 6-[18F]fluorohexanoate was further applied as a starting material for the preparation of the succinimide ester (NHS ester)-containing bifunctional radiofluorinated prosthetic group in two simple steps, 10 min each. The synthesized NHS ester of 6-[18F]fluorohexanoic acid can serve as an important reagent for a quick and efficient conjugation with peptides or proteins via amino groups of lysines.
CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS
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, (2009/10/30)
Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
