19578-80-4

Upstream product

• 7446-70-0 aluminium trichloride 
• 106-41-2 4-bromo-phenol 
• 100-44-7 benzyl chloride 
• 28994-41-4 o-Benzylphenol 
• 6793-92-6 p-benzyloxyphenylbromide 
• 615-58-7 2,4-dibromophenol 
• 1589-82-8 phenylmagnesium bromide 
• 100-39-0 benzyl bromide 
• 7647-01-0 hydrogenchloride 
• 324061-77-0 4-bromo-2-(hydroxy(phenyl)methyl)phenol 
• 7003-65-8 sodium 4-bromophenoxide 

Downstream Products

• 1188335-78-5 ethyl 2-(2-benzyl-4-bromophenoxy)acetate 
• 1188335-74-1 2-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 1188335-64-9 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid 
• 1188335-73-0 ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-ol-4-oxy)acetate 
• 1383790-70-2 ethyl 2-((2',3-dibenzyl-4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)acetate 
• 1383790-69-9 ethyl 2-((2,3'-dibenzyl-4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)acetate 
• 251895-12-2 1-(4-Benzyloxy)phenyl-2(S)-(tert-butoxycarbonyl)amino-3-phenyl-1-propanone 
• 41876-52-2 2-benzyl-4-bromoanisole 

Relevant academic research and scientific papers

Ortho-selective cross coupling of dibromophenols and dibromoanilines with grignard reagents in the presence of palladium catalysts bearing hydroxylated oligoarene-type phosphine

p-Terphenylphosphines with a hydroxy group were used as ligands for palladium in the catalytic cross coupling of dibromophenols and dibromoanilines with Grignard reagents. High ortho-selectivity that cannot be achieved with other phosphine ligands was observed. Copyright

One-pot migration-formylation of benzyl aryl ethers under Duff reaction condition

A one-pot migration-formylation of benzyl aryl ethers under Duff reaction condition is described. The reaction was performed with HMTA (hexamethylene tetramine) and TFA (trifluoroacetic acid). Under the optimal reaction conditions, a variety of Bn and PMB ethers underwent ortho rearrangement.

Synthesis of substituted asymmetrical biphenyl amino esters as alpha helix mimetics

As part of our ongoing project to develop new molecular probes for estrogen receptor-alpha, we are exploring the utility of internally-substituted asymmetric biphenyls as a proteomimetic scaffold. In this study, we describe synthetic methods for preparing

3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding

A series of bipolar biphenyl compounds was synthesized as proteomimetic analogs of the LXXLL penta-peptide motif responsible for the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were subjected

Hydroxylated terphenylphosphine ligands for palladium-catalyzed ortho-selective cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents

p-Terphenylphosphines bearing one or two hydroxy groups were used as ligands to palladium in the cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents. High ortho-selectivity that cannot be achieved using other phosphine ligands was observed. ortho-Preference was also observed in competitive cross-coupling reactions of two substrates. A significant effect of the concentration of the Grignard reagent on the ortho-selectivity was observed, when the hydroxylated terphenylphosphines were used. Kinetic studies on this effect showed that high concentrations of the Grignard reagent retard the cross-coupling reaction only at the para-position, but not at the ortho-position.

Synthesis of biphenyl proteomimetics as estrogen receptor-a coactivator binding inhibitors

"Chemical Equation Presented" A novel series of blphenyl proteomlmetic compounds were designed as estrogen receptor-α (ERα) coactivator binding Inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to li

MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING

Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.

Synthesis of substituted monohalobenzenes via ortho-selective cross-coupling of dihalobenzenes with electron-donating ortho-directing groups

Dihalobenzenes that possess directing groups such as OH, CH2OH, NH2, NHAc, or NHBoc were subjected to ortho-selective cross-coupling with Grignard reagents in the presence of palladium-based catalysts to give the corresponding substituted monohalobenzenes. For the dibromo- and dichlorophenols and anilines, hydroxylated terphenylphosphines 1 and 2 were found to be effective ligands for palladium, whereas tricyclohexylphosphine was preferable for the dichlorobenzyl alcohols, dichloroanilides, and difluorobenzenes. Georg Thieme Verlag Stuttgart.

Hydroxamic acid derivatives and medicinal utilization thereof

The present invention relates to a hydroxamic acid derivative of the formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the derivative or a salt thereof,

Proteomimetic compounds and methods

The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.