19757-97-2

Basic information

• Product Name: Methyl 2-hydroxy-2-methoxyacetate
• Synonyms: ACETIC ACID, HYDROXYMETHOXY- METHYL ESTER;2-HYDROXY-2-METHOXYACETIC ACID METHYL ESTER;METHYL 2-HYDROXY-2-METHOXYACETATE;GLYOXYLIC ACID METHYL ESTER METHYL HEMIACETAL;GMHA;hydroxymethoxyaceticacidmethylester;methyl hydroxymethoxyacetate;Methyl methoxyglycolate.
• CAS NO: 19757-97-2
• Molecular Formula: C₄H₈O₄
• Molecular Weight: 120.1
• EINECS: 243-271-2
• Mol File: 19757-97-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 128.128 °C at 760 mmHg
• Flash Point: 67°C
• Appearance: /
• Density: 1.174 g/cm³
• Vapor Pressure: 4.91mmHg at 25°C
• Refractive Index: 1.414
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.97±0.20(Predicted)
• Stability: Hygroscopic, Moisture Sensitive, Volatile
• CAS DataBase Reference: Methyl 2-hydroxy-2-methoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-hydroxy-2-methoxyacetate(19757-97-2)
• EPA Substance Registry System: Methyl 2-hydroxy-2-methoxyacetate(19757-97-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 19757-97-2(Hazardous Substances Data)

Usage

Uses

Methyl 2-?Hydroxy-?2-?methoxyacetate is a chemical reagent used in pharmaceutical synthesis such as the preparation of Bryostatin 1 derivatives which act as PKC-1 inhibitors in cancer therapy.

InChI:InChI=1/C4H8O4/c1-7-3(5)4(6)8-2/h3,5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 298-12-4 Glyoxilic acid 
• 922-68-9 Methyl glyoxylate 
• 107-31-3 Methyl formate 
• 98-01-1 furfural 
• 10028-15-6 ozone 
• 292638-85-8 acrylic acid methyl ester 
• 33414-80-1 2,4,6-trinitro anilino acetic acid ethyl ester 
• 124-41-4 sodium methylate 
• 563-96-2 2,2-dihydroxyacetic acid 
• 131543-46-9 Glyoxal 

Downstream Products

• 214621-93-9 methyl 2-(diphenylaminoimino)ethanate 
• 95205-00-8 methyl 2-(benzyloxyamino)butanoate 
• 6065-82-3 Ethyl diethoxyacetate 
• 1071-83-6 N-(phosphonemethyl)glycine 
• 199807-77-7 (+/-)-methyl 2-azabicyclo[2.2.1]hept-5-ene-3-exo-carboxylate 
• 199807-77-7 (+/-)-2-azabicyclo[2.2.1]hept-5-ene-3-endo-carboxylate 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 19377-70-9 α-hydroxy-2-furanacetic acid methyl ester 
• 947590-66-1 methyl 3-(1-hydroxy-2-methoxy-2-oxoethyl)benzoate 
• 83403-41-2 methyl 4-(1-hydroxy-2-methoxy-2-oxoethyl)benzoate 
• 156276-22-1 methyl 2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetate 
• 127709-20-0 α-hydroxy-(p-bromophenyl)-acetic acid methyl ester 
• 5766-41-6 methyl 2-(2,5-dimethylphenyl)-2-hydroxyacetate 
• 127357-38-4 N-(benzyloxycarbonyl)-α-hydroxy-glycine methyl ester 

Relevant articles and documents

Quinoline compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses a compound shown as a general formula I, pharmaceutically acceptable salt or metabolite of the compound, and a preparation method, a pharmaceutical composition and applicationof the compound. The compound shown in the general formula I, the pharmaceutically acceptable salt thereof or the metabolite thereof has a good treatment effect on virus infection, has small toxic andside effects, and can be used for preventing or treating virus infection.

CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF

There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R1 and R2 each independently represents an alkyl group having 1 to 10 carbon atoms and R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.

Experimental and DFT study of the aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine derivated from glyoxylates

The Diels-Alder reaction of protonated N-benzyl imine of methyl glyoxylate with cyclopentadiene in different solvents gave mixtures of exo/endo adducts. The exo/endo selectivity of the reaction was elucidated by NMR experiments. Theoretical calculations by means of density functional theory (DFT) at the B3LYP/6-31G(d) level have also been performed to elucidate the molecular mechanism of this reaction. The DFT results suggest a highly asynchronous concerted mechanism, which in turn can explain the preferred exo stereoselectivity of the reaction. Inclusion of solvent effects enhances the exo selectivity, and this effect increases with the polarity of the solvent, in good agreement with the experimental findings.