19757-97-2

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 2-hydroxy-2-methoxyacetate is used as a chemical reagent for the preparation of pharmaceutical compounds, specifically in the synthesis of Bryostatin 1 derivatives. These derivatives act as potent inhibitors of protein kinase C (PKC) isoforms, which play a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. By targeting PKC-1, these derivatives have the potential to be effective in cancer therapy, particularly in the treatment of solid tumors.
In the pharmaceutical industry, Methyl 2-hydroxy-2-methoxyacetate is used as a key intermediate in the synthesis of various drug candidates, owing to its unique chemical properties and reactivity. Its ability to form esters and ethers makes it a valuable building block for the development of novel therapeutic agents with potential applications in the treatment of various diseases, including cancer.

InChI:InChI=1/C4H8O4/c1-7-3(5)4(6)8-2/h3,5H,1-2H3

Upstream product

• 98-01-1 furfural 
• 67-56-1 methanol 
• 298-12-4 Glyoxilic acid 
• 131543-46-9 Glyoxal 
• 563-96-2 2,2-dihydroxyacetic acid 
• 922-68-9 Methyl glyoxylate 
• 107-31-3 Methyl formate 
• 10028-15-6 ozone 
• 292638-85-8 acrylic acid methyl ester 
• 33414-80-1 2,4,6-trinitro anilino acetic acid ethyl ester 
• 124-41-4 sodium methylate 

Downstream Products

• 89-91-8 Methyl dimethoxyacetate 
• 922-68-9 Methyl glyoxylate 
• 184353-69-3 methyl 2-(((benzyloxy)carbonyl)(methyl)amino)-2-hydroxyacetate 
• 214621-93-9 methyl 2-(diphenylaminoimino)ethanate 
• 188199-81-7 2-carbomethoxy-4⁽⁵⁾-(3',5'-dimethoxyphenyl)imidazole 
• 95205-00-8 methyl 2-(benzyloxyamino)butanoate 
• 1196-57-2 2-hydroxyquinoxaline 
• 278793-19-4 methyl (E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanate 
• 141565-14-2 N-(2-methoxy-2-oxoethylidene)-1-phenylmethanamine N-oxide 
• 287930-73-8 4-benzyl-2-hydroxy-morpholin-3-one 
• 875433-40-2 methyl 2-(1,3-dimethyl-2-oxocyclohexyl)-2-methoxyacetate 
• 851390-41-5 methyl (2Z)-{[(1R)-1-phenylethyl]imino}acetate 
• 6065-82-3 Ethyl diethoxyacetate 

Relevant academic research and scientific papers

Quinoline compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses a compound shown as a general formula I, pharmaceutically acceptable salt or metabolite of the compound, and a preparation method, a pharmaceutical composition and applicationof the compound. The compound shown in the general formula I, the pharmaceutically acceptable salt thereof or the metabolite thereof has a good treatment effect on virus infection, has small toxic andside effects, and can be used for preventing or treating virus infection.

POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF

There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R1 and R2 each independently represents an alkyl group having 1 to 10 carbon atoms and R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.

Imidazole based solid-supported catalysts for the benzoin condensation

New polymer-supported imidazolium salts have been synthesised, and their utility as pre-catalysts in the benzoin reaction has been demonstrated.

Experimental and DFT study of the aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine derivated from glyoxylates

The Diels-Alder reaction of protonated N-benzyl imine of methyl glyoxylate with cyclopentadiene in different solvents gave mixtures of exo/endo adducts. The exo/endo selectivity of the reaction was elucidated by NMR experiments. Theoretical calculations by means of density functional theory (DFT) at the B3LYP/6-31G(d) level have also been performed to elucidate the molecular mechanism of this reaction. The DFT results suggest a highly asynchronous concerted mechanism, which in turn can explain the preferred exo stereoselectivity of the reaction. Inclusion of solvent effects enhances the exo selectivity, and this effect increases with the polarity of the solvent, in good agreement with the experimental findings.

IMPROVED SYNTHESIS OF THE BIOLOGICALLY ACTIVE METHIONINE ANALOG, L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID (L-CIS-AMB) USING AN ELECTROPHILIC GLYCINATE SYNTHON

An improved synthesis of the methionine analog L-cis-AMB, is reported.The key step involves condensation of cis-methoxyvinyllithium with N-acetyl-α-bromoglycine methyl ester to give N-acetyl-DL-cis-AMB methyl ester, the penultimate intermediate of L-cis-AMB synthesis.

About the Ozone Cleavage of Chloroprene and of 2-Chloro-3-methyl-1,3-butadiene in Methanol

Monoozonolyses of chloroprene (1a) and of 2-chloro-3-methyl-1,3-butadiene (1b) in methanol occur with more than 90percent at the non-chlorinated double bonds to afford the corresponding α,β-unsaturated oxo compounds 2 with selectivities of 96 and 80percent respectively.The latter subsequently react with methanol, and 2a also with the complementary fragment methoxymethyl hydroperoxide (5).The α,β-unsaturated methoxy hydroperoxides 3 which have also been obtained, are less stable than similarly structured, non-α-chlorinated methoxy hydroperoxides.Diozonolyses of 1a and 1b in methanol afforded in 50-60percent the corresponding α-oxocarboxylates (21) and/or the corresponding ketals.In addition, anomalous products were obtained viz. ca. 15percent of methyl hydroxyacetate (12d) from 1a and 1b, as well as ca. 30percent of dimethyl oxalate (27b) from 1a and ca. 35percent of methyl acetate (13) from 1b.The modes of formation of these products have been postulated according to model reactions.

Formation of 4,6-Dinitro-2-nitrosoaniline by Intramolecular Redox Reaction of Esters and Amides of 2-(2,4,6-Trinitroaniline) Carboxylic Acids

The reaction of methyl and ethyl esters of N-(2,4,6-trinitrophenyl)glycine and N-(2,4,6-trinitrophenyl)-α-alanine (3a-d) with methoxide ion in methanol produces 4,6-dinitro-2-nitrosoaniline (4).N-(2,4,6-Trinitrophenyl)glycine methylamide (1d) gives, under the same conditions, the nitroso compound (4) in addition to 12percent of the spiro adduct (2d).A reaction mechanism is suggested, and the influence of the side chain on the reaction kinetics has been studied.

SYNTHESE HETEROCYCLISCHER -OXO-ESSIGSAEUREESTER MIT EINEM NEUEN ACYLANIONAEQUIVALENT

The synthesis of new heterocyclic -oxo-acetic acid esters with the novel and easily available acylanion equivalent 5 is described.