197958-49-9

Upstream product

• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 100-46-9 benzylamine 
• 108-88-3 toluene 
• 127-65-1 chloroamine-T 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 623-73-4 diazoacetic acid ethyl ester 
• 100-39-0 benzyl bromide 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 20158-69-4 2-(N-benzyl-4-methylphenylsulfonamido)acetic acid 

Downstream Products

• 7689-50-1 N-benzyl glycine hydrochloride 
• 197958-54-6 [Benzyl-(2,2-dimethyl-propionyl)-amino]-acetic acid ethyl ester 
• 197958-53-5 N-allyl-N-benzyl-2,2-dimethylpropanamide 
• 26209-45-0 N-benzyl-2,2-dimethylpropanamide 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 20158-69-4 2-(N-benzyl-4-methylphenylsulfonamido)acetic acid 

Relevant academic research and scientific papers

Facile amine formation by intermolecular catalytic amidation of carbon-hydrogen bonds

A simple copper-based catalytic system has been developed for the carbon-hydrogen amidation reaction. The copper-homoscorpionate complex Tp Br3Cu(NCMe) catalyzes the transfer of the nitrene unit NTs (Ts = p-toluenesulfonyl) and its subsequent insertion into the sp3 C-H bonds of alkyl aromatic and cyclic ethers or the sp2 C-H bonds of benzene using PhI=NTs as the nitrene source, affording the corresponding trisubstitued NR1HTs amines in moderate to high yields. The use of the environmentally friendly chloramine-T has also proven effective, with the advantage that sodium chloride is formed as the only byproduct. A tandem, one-pot consecutive nitrene-carbene insertion system has been developed to yield amino acid derivatives.

Reductive deprotection of allyl, benzyl and sulfonyl substituted alcohols, amines and amides using a naphthalene-catalysed lithiation

The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective.