19811-58-6Relevant articles and documents
Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives
Sharma, Nandini,Bahadur, Vijay,Sharma, Upendra K.,Saha, Debasmita,Li, Zhenghua,Kumar, Yogesh,Colaers, Jona,Singh, Brajendra K,Van der Eycken, Erik V.
supporting information, p. 3083 - 3089 (2018/08/24)
A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).
Catalyst and solvent-free amidation of inactive esters of N-protected amino acids
Nadimpally, Krishna Chaitanya,Thalluri, Kishore,Palakurthy, Nani Babu,Saha, Abhijit,Mandal, Bhubaneswar
supporting information; experimental part, p. 2579 - 2582 (2011/06/21)
A catalyst free procedure for the preparation of amides from inactive esters of N-protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.
Polymer Supported Reagents: Synthesis of Hippuric Acid Esters Using Anion Exchange Resin
Thorat, M. T.,Mane, R. B.,Jagdale, M. H.,Salunkhe, M. M.,Wadgaonkar, P. P.
, p. 809 - 810 (2007/10/02)
Polymer-supported nucleophilic reagent has been prepared by treatment of sodium salt of hippuric acid with Amberlite IRA-400 (Cl- form).This reagent when treated with appropriate alkyl halide in ethanol furnishes the corresponding hippuric acid
