19831-77-7Relevant academic research and scientific papers
Oxidative radical 1,2-alkylarylation of alkenes with α-C(sp3)-H bonds of acetonitriles involving 1,2-aryl migration
Li, Yang,Liu, Bang,Li, Hai-Bing,Wang, Qiuan,Li, Jin-Heng
, p. 1024 - 1026 (2014)
A novel metal-free oxidative 1,2-alkylarylation of unactivated alkenes with the α-C(sp3)-H bonds of acetonitriles for the synthesis of 5-oxo-pentanenitriles is presented. In the presence of TBPB (tert-butyl peroxybenzoate), a variety of α-aryl
C?C bond acylation of oxime ethers via NHC catalysis
Yang, Hai-Bin,Wan, Dan-Hong
supporting information, p. 1049 - 1053 (2021/02/01)
An N-heterocyclic carbene (NHC)-catalyzed strategy has been developed to address the issue of using toxic transitional metals in the field of C?C bond activation. The novel reaction mode enables an efficient docking between the cyanoalkyl from the cycloketone oxime derivative and the acyl group from the aldehyde, affording ketonitrile in moderate to good yields, which is one kind of useful building block for synthesizing nitrogen-containing pharmacophores.
Oxidative alkylation of alkenes with carbonyl compounds through concomitant 1,2-aryl migration by photoredox catalysis
Lin, Zhaowei,Lu, Maojian,Liu, Boyi,Gao, Jing,Huang, Mingqiang,Gan, Zhenhong,Cai, Shunyou
supporting information, p. 16031 - 16035 (2020/10/08)
Visible-light-enabled oxidative radical 1,2-alkylarylation of α-aryl allylic alcohols with carbonyl compounds has been established under mild conditions. An efficient and convenient protocol for the construction of a variety of 1,5-dicarbonyl compounds wa
Visible-light-induced 1,2-alkylarylation of alkenes with a-C(sp3)–H bonds of acetonitriles involving neophyl rearrangement under transition-metal-free conditions
Wang, Qiao-Lin,Chen, Zan,Zhou, Cong-Shan,Xiong, Bi-Quan,Zhang, Pan-Liang,Yang, Chang-An,Liu, Yu,Zhou, Quan
supporting information, p. 4551 - 4556 (2018/11/27)
An efficient visible-light-induced difunctionalization of alkenes with a-C(sp3)–H bonds of nitriles is described for the constructing of diverse 5-oxo-pentanenitriles under transition-metal-free conditions. This protocol proceeds via the functi
Reinventing the de Mayo reaction: Synthesis of 1,5-diketones or 1,5-ketoesters via visible light [2+2] cycloaddition of β-diketones or β-ketoesters with styrenes
Martinez-Haya, Rebeca,Marzo, Leyre,K?nig, Burkhard
supporting information, p. 11602 - 11605 (2018/10/31)
A visible light mediated De Mayo reaction between 1,3-diketones and styrenes following a [2+2] cycloaddition pathway via a photosensitization mechanism gives access to 1,5-diketones. The reaction has been applied to substituted styrenes and aryl- and alkyl-substituted ketones. Moreover, the method converts β-ketoesters, β-amido esters, and β-cyano ketones. Seven membered rings, a frequent structural motif of natural products, are also accessible using this methodology.
A General Stereocontrolled Synthesis of cis-2,3 Disubstituted Pyrrolidines and Piperidines
Pal, Kollol,Behnke, Mark L.,Tong, Liang
, p. 6205 - 6208 (2007/10/02)
A general synthetic method is reported for the preparation of cis-2,3-disubstituted pyrrolidines and piperidines from readily available acyclic precursors.The key reaction involves the stereoselective reduction of a cyclic imine controlled by the C-3 subs
