198478-48-7

Upstream product

• 57522-10-8 tetracarbonyl(2-phenylpyridine-κ²N,C⁸)manganese(I) 
• 100-44-7 benzyl chloride 
• 1008-89-5 2-phenylpyridine 
• 611-73-4 Benzoylformic acid 
• 2835-06-5 phenylglycin 
• 96-09-3 styrene oxide 
• 536-74-3 phenylacetylene 
• 93-56-1 phenylethane 1,2-diol 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 1074-12-0 phenylglyoxal hydrate 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 108-88-3 toluene 
• 622-76-4 1-phenyl-1-butyne 
• 673-32-5 1-Phenylprop-1-yne 

Downstream Products

• 1008-89-5 2-phenylpyridine 
• 219843-48-8 2-(biphenyl-2-yl)pyridine 
• 100-52-7 benzaldehyde 
• 1418179-24-4 C₂₃H₂₀N₂O₃S 
• 1334336-15-0 α-phenyl-(4-phenyl-2-(pyridin-2-yl))benzyl alcohol 
• 1418179-10-8 C₃₁H₂₆N₂O₂S 
• 1334336-26-3 C₂₄H₁₇NO 
• 1334336-75-2 (E,E)-2-(2-(4-methylstyryl)-6-styrylphenyl)pyridine 

Relevant academic research and scientific papers

Replacing Pd(OAc)2 with supported palladium nanoparticles in ortho-directed CDC reactions of alkylbenzenes

Supported palladium nanoparticles are used as efficient catalysts for the synthesis of aromatic ketones via cross dehydrogenative coupling reactions of 2-arylpyridines with alkylbenzenes. The catalyst can be reused for five cycles without significantly losing activity. Mechanism research showed that alkylbenzenes were oxidized to their corresponding aldehydes and subsequently coupled with 2-arylpyridines to generate aryl ketones through a Pd0/PdII/PdIV catalytic cycle.

Palladium nanoparticles supported on organofunctionalized kaolin as an efficient heterogeneous catalyst for directed C-H functionalization of arylpyrazoles

A heterogeneous catalyst system based on the immobilization of Pd0 nanoparticles onto organofunctionalized kaolin is reported with a view to introducing new synthetic routes of directed C-H functionalization of arylpyrazoles. Various characterization techniques revealed that the functional groups, 3-aminopropyltriethoxysilane (APTES) and phenyltrimethoxysilane, become strongly attached to the kaolin surface through Si-O-Si bonds and 3-6 nm sized Pd0 nanoparticles are uniformly decorated and stabilized through the organic amine moieties. The nano-palladium catalyst is durable, undergoing five times reuse with moderate catalytic activity. The XPS analysis of the catalyst before and after reaction suggested that the reaction might be performed via a catalytic cycle that begins with Pd0.

Reaction of organolithium reagents with cyclorhenated and cyclomanganated (η6-arene)tricarbonylchromium complexes: Structural characterization of a new benzoylrhenate intermediate and selective ortho-acetylation of (η6-arene)tricarbonylchromium complexes

The nucleophilic addition of PhLi to tetracarbonyl[3-methyl-2-{(η 6-phenyl)tricarbonylchromium-(0)}pyridine]rhenium(I) yields the air-stable (exo-benzoyl)(tricarbonyl)[3-methyl-2-{(η 6-phenyl)tricarbonylchromium(0)-κC 2′}pyridine-κN]rhenate(I) that has been isolated and characterized by X-ray diffraction analysis and other spectroscopic methods. A similar treatment applied to cyclomanganated (η6-arene)Cr(CO)3 analogues with a nucleophile such as MeLi provides a new route to the synthesis of ortho disubstituted (η6-acetophenone)Cr(CO)3 derivatives.

Monodisperse CuPd alloy nanoparticles as efficient and reusable catalyst for the C (sp2)–H bond activation

Metal-catalyzed selective activation of C–H bonds is very important for the construction of a variety of biologically active molecules. Supported alloy nanoparticles are of great interest in various catalytic applications due to the synergistic effects between different metals. Here, well-dispersed CuPd alloy nanoparticles supported on reduced graphene oxide (rGO) were synthesized and found to be highly efficient and recyclable catalyst for the chelation-assisted C (sp2)–H bond activation. Aromatic ketones or esters were synthesized via the cross-dehydrogenative coupling (CDC) reaction between 2-arylpyridines and alcohols or acids. Moreover, the catalyst was recovered and used for five times without significantly losing activity.

Acylation of Arenes with Aldehydes through Dual C-H Activations by Merging Photocatalysis and Palladium Catalysis

An acylation of arenes with aldehydes through dual C-H activations at room temperature is reported. The acylation was initiated by phenanthraquinone-catalyzed hydrogen atom transfer from aldehyde under visible light irradiation. The aldehyde-derived acyl

A Strategy for Amide C-N Bond Activation with Ruthenium Catalyst: Selective Aromatic Acylation

A strategy for amide C-N bond activation with ruthenium catalyst is described for the first time. The in situ formed bis-cycloruthenated complexes were demonstrated to be the key active species with superior oxidative addition ability to an inert amide C-N bond. The direct C-H bond activation of 2-arylpyridines followed by the amide C-N bond activation took place in the presence of a ruthenium precatalyst to produce monoacylation products in moderate to good yields. Synthetically useful functional groups, such as halogen atoms (F and Cl), ester, acetyl, and vinyl, remained intact during tandem C-H/C-N bond activation reactions.

Preparation method of nitrogen-containing heterocyclic diarylketone compound

The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry, and provides a preparation method of a nitrogen-containing heterocyclic diarylketone compound. According to the method, N,N-phenyl p-toluenesulfonyl benzamide and derivatives thereof are used as acylation reagents and are subjected to a C-H acylation reaction with a 2-phenylpyridine compound in an anhydrous organic solvent under the action of a metal catalyst, a ligand, carboxylic acid and an alkali to be converted into the nitrogen-containing heterocyclic diarylketone compound. According to the preparation method of the nitrogen-containing heterocyclic diarylketone compound, reaction steps are few, amide widely existing in the nature is used as an acyl source, and the nitrogen-containing heterocyclic diarylketone compound is environmentally friendly, low in price, mild in reaction condition and convenient to operate; and the target product is obtained with high yield and high selectivity, and the method has good industrial production value and practical application value. The diarylketone compound synthesized by the method can be subjected to further functionalization reaction, and can be widely applied to the fields of synthesis of medicines, pesticides, bioactive molecules, functional material molecules and the like.

Silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary alcohols

A silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. This general procedure delivers ketones with high atom-economy and hydrogen was the sole byproduct. This dehydrogenation reaction has a good functional group tolerance and high efficiency (up to 90% yield and 10,000/1 substrates-to-catalyst ratio).

Dual photoredox/palladium-catalyzed C-H acylation of 2-arylpyridines with oxime esters

An unprecedented dual photoredox/palladium-catalyzed iminyl-radical-mediated C-C bond cleavage and directed ortho C-H acylation of 2-arylpyridines by using oxime esters is described. Oxime esters can serve as efficient acyl sources through formation of the corresponding acyl radicals by photoredox-catalyzed iminyl-radical-mediated C-C bond cleavage. This redox-neutral protocol features excellent regioselectivity, a broad substrate scope, and good functional-group tolerance with respect to both components, giving a broad range of aryl ketones with generally good yields.

Ruthenium-Catalyzed Carbonylative Coupling of Anilines with Organoboranes by the Cleavage of Neutral Aryl C-N Bond

Herein, we report the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines via C(aryl)-N bond cleavage. Without any ligand and base, diaryl ketones can be obtained in moderate to high yields by using Ru3/su