19857-47-7

Upstream product

• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 106-40-1 4-bromo-aniline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 50735-55-2 2-amino-N-(4-bromophenyl)benzamide 
• 119072-55-8 tert-butylisonitrile 
• 98-80-6 phenylboronic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 2385-26-4 N-(4-bromophenyl)-2-nitrobenzamide 
• 100-51-6 benzyl alcohol 
• 698-16-8 benzohydroximoyl chloride 
• 780-20-1 N-benzylidene-4-bromoaniline 
• 1437798-56-5 4-(4-bromophenyl)-3,5-diphenyl-4,5-dihydro-1,2,4-oxadiazole 
• 3084-52-4 2-phenyl-4H-1,3-benzoxazin-4-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones

A novel palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.

Iron-catalyzed one-pot 2,3-diarylquinazolinone formation from 2-nitrobenzamides and alcohols

A novel approach for the synthesis of 2,3-diarylquinazolinones using iron as catalyst is described. Various 2-nitro-N-arylbenzamides reacted with benzylic alcohols to selectively give the corresponding products in the absence of external oxidant or reduct

Oxidative radical skeletal rearrangement induced by molecular oxygen: Synthesis of quinazolinones

Oxidative skeletal rearrangement of 5-aryl-4,5-dihydro-1,2,4-oxadiazoles into quinazolinones is induced by molecular oxygen (under a dry air atmosphere) that likely proceeds via transient iminyl radical species. Concise syntheses of biologically active qu

Evaluation of antibacterial activity of novel quinazoline derivatives

In the present study, a series of novel quinazoline derivatives were synthesized by condensation with different aromatic amines via cyclized intermediate 2-phenyl-1,3-benzoxazin-4-one. The chemical structures were confirmed by means of IR and 1H NMR. These compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Escherichia coli ATCC-25922, activities by paper disc diffusion technique. The potency of antibiotic content in samples can be determined by chemical, physical or biological means. An assay is made to determine the ability of an antibiotic to kill or inhibit the growth of living microorganism. The inhibition of microbial growth under standardized conditions may be utilized for demonstrating the therapeutic efficacy of drugs. Microorganism employed in biological assay are of various typesbacteria for amino acid, antibiotics, fungi for vitamins, trace elements, antibiotics and fungicidal and fungi static materials. The synthesized compounds were evaluated for antibacterial activity. Some of these synthesized compounds shown significant antibacterial activity.