4361-96-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure and properties make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Antioxidant Applications:
3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is used as an antioxidant agent for its potential to protect cells and tissues from oxidative damage. Its antioxidant properties can be harnessed to develop new treatments for various diseases and conditions associated with oxidative stress.
Used in Antimicrobial Applications:
3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is used as an antimicrobial agent due to its potential to inhibit the growth of harmful microorganisms. This property can be utilized in the development of new antimicrobial drugs and therapies to combat bacterial and fungal infections.
Used in Anti-inflammatory and Analgesic Applications:
3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is used as an anti-inflammatory and analgesic agent in preclinical studies. Its ability to reduce inflammation and alleviate pain makes it a promising candidate for the development of new treatments for inflammatory and pain-related conditions.
Overall, 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is a versatile chemical compound with a wide range of potential applications in various industries, particularly in the fields of chemistry, pharmacology, and drug development. Its unique properties and promising research outcomes have attracted the attention of scientists and researchers, who are actively exploring its potential uses and benefits.

InChI:InChI=1/C17H12O2/c18-17-15(11-13-7-3-1-4-8-13)12-16(19-17)14-9-5-2-6-10-14/h1-12H

Upstream product

• 158426-75-6 2-benzylidene-4-phenyl-but-3-enoic acid 
• 127157-60-2 2-benzyl-2-hydroxy-4-oxo-4-phenyl-butyric acid 
• 100-52-7 benzaldehyde 
• 2051-95-8 succinylbenzene 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 51615-57-7 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylic acid 
• 10035-10-6 hydrogen bromide 
• 904819-19-8 β-truxinamic acid 
• 7596-81-8 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylic acid dimethyl ester 
• 861330-34-9 (2-bromo-3-oxo-1,3-diphenyl-propyl)-malonic acid dimethyl ester 
• 40616-05-5 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylic acid monomethyl ester 

Downstream Products

• 102756-66-1 1-(2-phenacyl-3ξ-phenyl-acryloyl)-piperidine 
• 65155-72-8 2-phenacyl-3-phenyl-acrylic acid benzylamide 
• 57999-77-6 α-phenacylcinnamic acid 
• 17560-24-6 1-phenylnaphthalene-3-carboxylic acid 
• 5666-05-7 2-benzyl-4-phenylbutanoic acid 
• 77811-59-7 4-Oxo-4-phenyl-2-[1-phenyl-meth-(Z)-ylidene]-butyric acid N'-phenyl-hydrazide 
• 77811-54-2 N-Methyl-4-oxo-4-phenyl-2-[1-phenyl-meth-(Z)-ylidene]-butyramide 
• 101536-89-4 5-Phenyl-3-[1-phenyl-meth-(E)-ylidene]-3H-furan-2-thione 
• 93328-60-0 4-(4-Chlor-phenyl)-2-naphthoesaeure 
• 50558-51-5 4-phenylnaphtho[2,3-c]firan-1(3H)-one 

Relevant academic research and scientific papers

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

A ligand-based approach was applied to screen in silico a library of commercially available compounds, with the aim to find novel inhibitors of the HCV replication starting from the study of the viral NS3 helicase. Six structures were selected for evaluat

A new ferrocenyl bisphosphorus ligand for the asymmetric hydrogenation of α-methylene-γ-keto-carboxylic acids

Upon incorporation of a noncovalent ion pair interaction, a new chiral ferrocenyl bisphosphorus ligand t-Bu-Wudaphos was developed. t-Bu-Wudaphos can be easily synthesized with very high diastereoselectivity as a highly air stable solid. The new ligand exhibited excellent reactivities and enantioselectivities in the asymmetric hydrogenation of α-methylene-γ-keto-carboxylic acids via an ion pair noncovalent interaction (up to >99% conversion, >99% ee).

Microwave assisted Perkin reaction for the synthesis of α-arylidine-γ-phenyl-Δ, β, γ-butenolides

Perkin condensation with subsequent intramolecular lactonisation as one pot synthesis of α-arylidine-γ-phenyl-Δ,β,γ- butenolides have been studied under microwave irradiation. The butenolides are cleaved to give keto acids, which are the precursors of pericarbonyl lactone lignans possessing variety of biological activities. Syntheses of butenolides have been carried out using pyridine as a catalyst under microwave conditions. The generality of this protocol has been demonstrated by synthesizing a variety of substituted butenolides in excellent yields, short reaction time and with good purity compared to those under classical thermal conditions. All the products have been characterized by their IR, 1H NMR and UV spectral values.

Aryl formate as bifunctional reagent: Applications in palladium-catalyzed carbonylative coupling reactions using in situ generated CO

After decades of development, carbonylation reactions have become one of the most powerful tools in modern organic synthesis. However, the requirement of CO gas limits the applications of such reactions. Reported herein is a versatile and practical protocol for carbonylative reactions which rely on the cooperation of phenyl formate and nonaflate, and the generation of CO in situ. This protocol has a high functional-group tolerance and could be applied in carbonylations with C, N, and, O nucleophiles. The corresponding amides, alkynones, furanones, and aryl benzoates were synthesized in good yields. Transformers: A versatile and practical protocol for carbonylation reactions involve the cooperation of phenyl formate and nonaflate with generation of CO in situ. This protocol has a high functional-group tolerance and could be applied in carbonylative couplings with C, N, and O nucleophiles. The corresponding amides, alkynones, furanones, and aryl benzoates were synthesized in good yield.

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

Synthesis of 1-phenyl naphthalene and pericarbonyl lignans

The approach towards synthesis of 1-phenyl naphthalene and pericarbonyl lactone by cyclization of Perkin condensation product, ∝- arylidene β-benzoyl propionic acid with polyphosphoric acid and concentrated sulphuric acid can be achieved in one step.

Electronic absorption spectra of arylmethylene, ethylidene, and allylidene 3H-furan-2-one derivatives

The electronic absorption spectra of 3H-furan-2-ones containing substituents with varied length of the conjugation chain in position C 3 of the heteroring are examined. The conclusions are made about the direction of the band shift depending on

NEW COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYES AND PIGMENTS

Compounds of formula (1) wherein R1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic amide, alkoxy, aryloxy, alkylthio or arylthio, X is -0-, -S-, -NH- or -N(alkyl)-, Y is hyd

A highly efficient methodology for the synthesis of α-arylidene-γ-aryl-Δβ,γ-butenolides using microwaves

A highly efficient and practical methodology for the synthesis of α-arylidene-γ-aryl-Δβ,γ-butenolides is described starting from aryl propionic acids and aryl aldehydes under microwave conditions.