209340-51-2

Usage

Uses

Used in Ophthalmology:
C₃₃H₄₀N₂O₈S₂ is used as a local anesthetic for numbing the eyes during eye examinations or minor eye surgeries. It is administered in the form of eye drops to provide temporary relief from discomfort and pain.
Used in Dentistry:
C₃₃H₄₀N₂O₈S₂ is used as a local anesthetic in dental procedures, such as tooth extractions, root canals, and dental surgeries. It is applied topically in the form of a jelly or cream to numb the area and minimize pain during the treatment.
Used in Minor Surgical Procedures:
C₃₃H₄₀N₂O₈S₂ is used as a local anesthetic for minor surgical procedures, such as skin biopsies, suturing, and wound management. It is applied to the affected area to numb the skin and reduce pain during the procedure.

Upstream product

• 146368-08-3 1-(5-carboxypentyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 146368-07-2 1-Ethyl-2,3,3-Trimethylindolenineninium 5-Sulfone 
• 4224-70-8 6-bromohexanoic acid 
• 51143-32-9 malonaldehyde bis(phenylimine) monohydrochloride 
• 146397-21-9 C₂₄H₂₆N₂O₄S 
• 132557-72-3 2,3,3-trimethylindole-5-sulfonic acid 
• 563-80-4 3-methyl-butan-2-one 
• 98-71-5 4-hydrazino-benzenesulfonic acid 

Downstream Products

• 917979-27-2 3H-indolium-2-[(1E,3E,5E)-5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadienyl]-1-ethyl-3,3-dimethyl-5-sulfo-, inner salt, succinimidyl ester 
• 1246943-82-7 Cy 5 
• 1246943-82-7 Cy₅-NHS 
• 917979-27-2 C₃₇H₄₃N₃O₁₀S₂ 

Relevant academic research and scientific papers

An efficient approach to the synthesis of water-soluble cyanine dyes using poly(ethylene glycol) as a soluble support

An efficient synthesis approach to unsymmetrical water-soluble cyanine dyes has been established. Loading and activation of sulfoindolenium to poly(ethylene glycol) (PEG) have been achieved via a simple strategy. Cyanine dyes are released by the attack of heterocyclic carbon nucleophile and the cleavage of PEG-bound hemicyanine. The efficient approach delivers cyanine dyes in high purity without the nontrivial chromatographic separation.

FLUORESCENCE COMPOUNDS AND PREPARATION METHOD THEREOF

Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.

Cyanine compound for labeling biomolecule and preparation method thereof

Disclosed are a novel cyanine compound, represented by the following Formula 1, for labeling biomolecules, and a method for preparing the same. wherein R1, R2, R3, R4, B, m and n are defined as above.

Synthesis of PEG derivatives bearing aminophenyl and their application for liquid-phase synthesis of water-soluble unsymmetrical cyanine dyes

The synthesis and NMR characterization of soluble PEG-supported polymers were described, and their subsequent application for liquid-phase synthesis of water-soluble cyanine dyes was also studied. Nucleophilic substitution of tosylation of PEG 16 with 1,3-bis(4-nitrophenoxy)-2-propanol 15 under basic conditions, followed by nitro group reduction, gave PEG-bound aminophenyl 18. Another PEG-bound aminophenyl 28 was prepared by condensation reaction of PEG-bound pentaerythritol 25 and 4-aminobenzoic acid followed by the cleavage of BOC group. Subsequent loading and activation of sulfoindoleninium to PEG derivatives 18 or 28 were achieved via simple strategies. Cyanine dyes were released by the attack of heterocyclic carbon nucleophile and the cleavage of PEG-bound hemicyanine without the chromatographic separation. The efficient, facile, and practical approaches appear to be robust and versatile strategies to deliver not only indocyanine dyes but also benzoindocyanine dyes.

PH sensitive cyanine dyes as reactive fluorescent reagents

The present invention provides pH sensitive cyanine dyes having the structure (I) wherein X and Y are independently selected from >C(C1 - C4alkyl)2, sulfur and oxygen; R1 and R2 are independently selected from H, CH2NH2, SO3-, phosphate, phosphonate, quaternary ammonium, (CH2)qCOOH, NCS, CH2NH-COR7, where R7 is C1 - C20 straight or branched alkyl and (CH2)qCOOH where q is an integer from 0 - 10; R3 is H or -L-P where L is selected from C1 - C20 straight or branched alkyl optionally containing 0, 1 or 2 unsaturated groups selected from alkenyl and alkynyl, and P is selected from a reactive group, H, C1 - C20 straight or branched alkyl, SO3-, NH2, quaternary ammonium, CH2NH-COR8, where R8 is C1 - C20 straight or branched alkyl, -(CH2)mCOOH, NHR9 where R9 is C1 - C20 straight or branched alkyl; n is an integer from 0 - 3; p and r are independently 0, 1, 2, 3 or 4 and where p and/or r is greater than 1, each R1 and each R2 may be different, and m is an integer from 1 - 10; and salts and protonated derivatives thereof and methods of using same as fluorescent reagents.