21021-60-3

Basic information

• Product Name: Ethanethioic acid, S-(4-chlorophenyl) ester
• CAS NO: 21021-60-3
• Molecular Formula: C8H7ClOS
• Molecular Weight: 186.662
• Mol File: 21021-60-3.mol
• Article Data: 36

Chemical Properties

• CAS DataBase Reference: Ethanethioic acid, S-(4-chlorophenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanethioic acid, S-(4-chlorophenyl) ester(21021-60-3)
• EPA Substance Registry System: Ethanethioic acid, S-(4-chlorophenyl) ester(21021-60-3)

Safety Data

• Hazardous Substances Data: 21021-60-3(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 106-54-7 p-Chlorothiophenol 
• 75-36-5 acetyl chloride 
• 2754-27-0 trimethylsilyl acetate 
• 30718-19-5 (4-chlorophenylthio)trimethylsilane 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 1971-49-9 N-acetylphthalimide 
• 64-19-7 acetic acid 
• 108-22-5 Isopropenyl acetate 
• 106-47-8 4-chloro-aniline 
• 10387-40-3 potassium thioacetate 
• 15119-62-7 1-acetylsulfanyl-4-nitro-benzene 
• 18803-44-6 sodium p-chlorothiophenolate 
• 830-03-5 4-nitrophenol acetate 

Downstream Products

• 123-09-1 4-chlorophenyl methyl sulfide 
• 193765-63-8 4-chlorophenyl dithioacetate 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 1200863-94-0 C₁₄H₁₇ClO₂S 
• 1372616-57-3 C₁₈H₁₀Cl₂F₂S₂ 
• 1376608-73-9 C₁₂H₇ClF₂S 
• 54083-62-4 4,4-Bis-(4-chloro-phenylsulfanyl)-1,1,1-trifluoro-but-3-en-2-one 
• 60-35-5 acetamide 
• 35337-68-9 4-Chloro-benzenethiol anion 
• 64-19-7 acetic acid 
• 106-54-7 p-Chlorothiophenol 

Relevant articles and documents

Solvent-free acetylation of thiols under catalysis of MgBr 2·OEt2

Solvent-free protection of aromatic and aliphatic thiols with acetic anhydride was performed at room temperature under trace quantities of magnesium bromide ethyl etherate, affording rapid formation of various thiol esters in excellent yields. Copyright Taylor & Francis Group, LLC.

Methanesulfonic anhydride-promoted sustainable synthesis of thioesters from feedstock acids and thiols

Abstract: An unprecedented metal-, halogen- and solvent-free, MSAA-promoted S-carbonylation of thiols with feedstock acids has been developed. This new transformation provides an efficient and atom-economic strategy for the synthesis of thioesters in a single operation from readily available and inexpensive starting materials. The reaction avoids the use of expensive and hazardous coupling reagents, bases and generates water as the only by-product, thus making this chemical synthetic process more viable, environment-friendly and contributing towards sustainable chemistry. Graphic abstract: [Figure not available: see fulltext.].

Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C–S and C–Se bond formation

An air-stable μ-oxo-bridged binuclear Lewis acid of titanium(IV) salophen perfluorobutanesulfonate [{Ti(salophen)H2O}2O][OSO2C4F9]2 (1) was successfully synthesized by the reaction of TiIV(salophen)Cl2 with AgOSO2C4F9 and characterized by techniques such as IR, NMR and HRMS. This complex was stable open to air over a year, and exhibited good thermal stability and high solubility in polar organic solvents. The complex also had relatively strong acidity with a strength of 0.8 Ho ≤ 3.3, and showed high catalytic efficiency towards various C–S and C–Se bond formations in the presence of zinc power. This catalytic system affords a mild and efficient approach to synthesis of thio- and selenoesters, α-arylthio- and seleno-carbonyl compounds, and thio- and selenoethers.

Air-Tolerant Direct Thiol Esterification with Carboxylic Acids Using Hydrosilane via Simple Inorganic Base Catalysis

Direct thioesterification of carboxylic acids with thiols using nontoxic activation agents is highly desirable. Herein, an efficient and practical protocol using safe and inexpensive industrial waste polymethylhydrosiloxane as the activation agent and K3PO4 with 18-crown-6 as a catalyst is described. Various functional groups on carboxylic acid and thiol substituents can be tolerated by the present system to afford thioesters in yields of 19-100%.