210962-91-7

Basic information

• Product Name: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE
• Synonyms: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE;N-TBOC-P-IODO-D-PHENYLALANINE METHYL ESTER;Boc-4-iodo-D-phenylalanine methyl ester
• CAS NO: 210962-91-7
• Molecular Formula: C15H21ClINO4
• Molecular Weight: 441.69
• Mol File: 210962-91-7.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(210962-91-7)
• EPA Substance Registry System: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(210962-91-7)

Safety Data

• Hazardous Substances Data: 210962-91-7(Hazardous Substances Data)

Usage

Description

METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE is a chemical compound with a molecular formula of C16H22INO4, derived from the amino acid leucine. It is a white solid at room temperature, insoluble in water, and soluble in organic solvents. METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE is commonly used as a building block in the synthesis of peptide molecules and plays a crucial role in the development of new pharmaceuticals and research chemicals.

Uses

Used in Pharmaceutical Industry:
METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE is used as a building block for the synthesis of peptide molecules, which are essential components of various pharmaceuticals and medications. Its unique structure and properties make it a valuable asset in the development of new drugs and medications.
Used in Research Chemicals:
METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE is also used in the preparation of research chemicals, where it serves as a key component in the synthesis of various compounds. Its versatility and reactivity make it an important tool for researchers in the field of chemistry and pharmaceuticals.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1991-81-7 p-iodophenylalanine 
• 74-88-4 methyl iodide 
• 103882-09-3 N-Boc-DL-4-iodophenylalanine 
• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 372967-43-6 (R)-methyl 2-amino-3-(4-iodophenyl)propanoate 
• 62561-75-5 (R)-2-amino-3-(4-iodophenyl)propanoic acid 
• 34619-03-9 tert-butyldicarbonate 
• 67-56-1 methanol 
• 1991-81-7 4-iodo-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 103882-09-3 N-Boc-4-I-Phe-OH 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 123993-30-6 (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester 
• 850610-04-7 tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(benzenesulfonyl)phenyl)ethylcarbamate 

Relevant articles and documents

Preparation method of sacubitril intermediate

The invention relates to the technical field of synthesis of medical intermediates, in particular to a preparation method of a sacubitril intermediate, which comprises the following steps: 1) reacting a raw material compound III with phosphorus trihalide to obtain a compound II; and 2) reacting the compound II with phenylhydrazine in the presence of a catalyst and an additive to obtain a sacubitril intermediate, namely a compound I. According to the invention, cheap phosphorus trihalide is selected to replace expensive and highly toxic trifluoromethanesulfonic anhydride, and cheap phenylhydrazine and a catalyst palladium chloride are adopted. The method has the advantages of simple reaction operation, low cost and high yield, and is easier for industrial production of the compound I.

Facile synthesis of a novel genetically encodable fluorescent α-amino acid emitting greenish blue light

We report the facile synthesis and characterization of a novel fluorescent α-amino acid 4-phenanthracen-9-yl-l-phenylalanine (Phen-AA) (5) that emits greenish blue light in the visible region. This genetically encodable l-α-amino acid has excellent photostability with a 75% quantum yield. It readily gets into human cells, being clearly imaged upon 405 nm laser excitation. The synthetic procedure is resistant to racemization and only involves three simple steps which use mild conditions and generate the Phen-AA in reasonably good yield. It may find broad applications in research, biotechnology, and the pharmaceutical industry.

Electrochemical synthesis of 1,2-diketones from alkynes under transition-metal-catalyst-free conditions

We report an electrochemical protocol for the direct oxidation of internal alkynes in air to provide 1,2-diketones. A variety of functional groups and heterocycle-containing substrates can be tolerated well under mild conditions.