211310-10-0Relevant articles and documents
Construction of azaspirocyclic skeletons mediated by the carbonyl of the Weinreb amide: Formal total synthesis of (±)-cephalotaxine
Ding, Huili,Fan, Yuxue,Jiang, Minghua,Li, Shanshan,Liu, Jianyin,Liu, Lu,Liu, Tianfu,Zhang, Jian
supporting information, p. 1879 - 1882 (2022/03/15)
A facile Stevens rearrangement of the Weinreb amide and the subsequent key steps mediated by the carbonyl of the Weinreb amide led to the construction of azaspirocyclic skeletons of some typical alkaloids. And the formal total synthesis of (±)-cephalotaxine was completed via a shorter synthetic route by this efficient method. Further studies on the development and asymmetric synthesis application of this strategy are underway. This journal is
MODIFIED PROTEINS AND PROTEIN DEGRADERS
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Paragraph 001422-001424, (2021/12/08)
Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
Rh2(II)-catalyzed selective aminomethylene migration from styryl azides
Kong, Chen,Jana, Navendu,Driver, Tom G.
, p. 824 - 827 (2013/03/29)
Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.
